Coxiella burnetii antigens may induce resistance to tumour growth.

Coxiella burnetii antigens stimulate the defence against growth of hepatoma 22a cells. The antigen-stimulated mice survived longer, they considerably later developed palpable tumours and showed a retarded tumour growth. The enhanced resistance to tumour growth may be explained by at least 2 interrelated phenomena; namely by the induction of interferon-like activity and an increased NK cell activity.

Allergic syndrome in chronic cholecystitis and colitis, the efficiency of specific hyposensitivity with microbic allergen.

In more than 1000 patients with noncalculous cholecystitis, chronic colitis (nonulcerative, nonspecific ulcerative, Crohn's disease of the bowel) and with dyskinesia of intestine the participation of allergic components was investigated in the development and chronic duration of the diseases. More often was observed the sensibilization to bacteria of conditionally pathogenetic microflora (E. coli, staphylococcus, streptococcus, proteus) that was confirmed by positive skin tests, sensibilization of lymphocytes to microbic allergens, increase of the titer of microbic antibodies in blood.

Specific bacterial immunotherapy in chronic colitis.

Three hundred and fifteen patients with chronic nonulcerative colitis were studied. Two hundred patients were given specific immunotherapy by bacterial allergens, and 115 formed the control group. Immunotherapy was carried out with increasing doses of bacterial allergens - E Coli, Streptococcus, Staphylococcus or Proteus - for 1-2 years.