Practical application of multimodality imaging for cardio-oncology in Latin America.

Latin America (LA) is one of the regions in the world with the highest levels of overweight, dyslipidemia, and diabetes mellitus, which, together with smoking and high blood pressure, are common risk factors for cardiovascular and oncological diseases. Chemotherapy (CT) and Radiotherapy (RT) have become two of the mainstays of treatment for several types of cancer. One of the most worrisome side effects generated by CT and RT is cardiotoxicity.

Effectiveness of Acceptance and Commitment Therapy on Mental Health Issues: A Systematic Review.

Background: Mental health disorders rank among the most common psychiatric conditions, with lifetime prevalence rates that have a significant effect on the global population. Although CBT is still the most generally recommended psychosocial intervention for mental health problems, a significant number of patients do not fully react to therapy, which results in persistent symptoms. Acceptance and Commitment Therapy (ACT) has gained worldwide attention as a promising intervention with a growing body of empirical support across a variety of mental health conditions.

A contribution on first report of morphogenetic characterization of parasitizing Indian sand whiting, from Central west coast of India.

The search for hitherto undiscovered larvae of sp. from marine habitat in the Indian sub-continent yielded (Dujardin) larvae hitherto unconfirmed. The present study is the maiden attempt to report 3 stage larvae of from the reef-associated in Arabian Sea off the coast of Goa, which has been identified recently as reef-populated area within the maritime boundary of India.

Using machine learning to identify risk factors for short-term complications following thumb carpometacarpal arthroplasty.

Background: Thumb carpometacarpal (CMC) joint osteoarthritis is among the most common degenerative hand diseases. Thumb CMC arthroplasty, or trapeziectomy with or without tendon augmentation, is the most frequently performed surgical treatment and has a strong safety profile. Though adverse outcomes are infrequent, the ability to predict risk for complications has substantial clinical benefits.

Nitrogen-bridgehead compounds: overview, synthesis, and outlook on applications.

The nitrogen-bridgehead is a common structural motif present in a multitude of natural products. As many of these abundant compounds exhibit biological activities, against cancer or bacteria, these derivatives are of high interest. While natural products are often associated with problematic characteristics, such as elaborate separation processes, high molecular complexity and limited room for derivatization, purely synthetic approaches can overcome these challenges.

Comparative efficacy and safety of gabapentin, pregabalin, oxcarbazepine, and duloxetine in diabetic peripheral neuropathy: A network meta-analysis.

Purpose: To conduct a network meta-analysis comparing the safety and efficacy of gabapentin (GBP), pregabalin (PGB), oxcarbazepine (OXC), and duloxetine (DLX) in treating diabetic peripheral neuropathy (DPN).

Materials And Methods: The study's eligibility criteria includee randomized controlled trials (RCTs) with a focus on DPN patients receiving GBP, PGB, DLX, or OXC versus placebo. Noncompliant trials with incomplete information and observational studies were excluded.

Assessment of attitudes of health professionals toward naloxone use.

Purpose: To assess the attitudes and behaviors of physicians, hospital pharmacists, registered nurses, and other healthcare professionals toward naloxone use. This survey will help the University Medical Center New Orleans Analgesic Management Stewardship team understand barriers and determine the education needed to improve the care we provide.

Methods: A survey was conducted at a single center, and it contained 17 questions: two concerning provider type and practice setting, followed by 15 qualitative questions to be answered in a Likert scale format, with options ranging from strongly disagree to strongly agree.

promising immunotherapeutic intervention for diseases.

Immunomodulating agents interact with the immune system and alter the outcome of specific immune processes. As our understanding of the immune system continues to evolve, there is a growing effort to identify agents with immunomodulating applications to use therapeutically to treat various diseases. (Mw), a heat-killed mycobacterium, is an atypical mycobacterial species that possesses strong immunomodulatory properties.

Amend the Mental Health Care Act 2017: A Survey of Indian Psychiatrists (Paper 1).

Aim: This paper highlights the difficulties and lacunae in the Mental Health Care Act 2017 that hinder its implementation and use for the care and treatment of persons with mental illness in India.

Methods: An online nationwide survey, involving structured questions as well as open-ended questions, to elicit the level of implementation, experience in complying with the provisions of the Act, and level of satisfaction, of practicing psychiatrists was carried out. Responses were analyzed using appropriate statistics.

Barriers, blocks, and barricades: Disparities to access of palliative care in cancer care.

Palliative care (PC) is specialized medical care for people living with a serious illness. PC models have stressed pain and symptom management, communication that is patient- and family-centric and longitudinal support for families living with serious illness that is contiguous across multiple settings. Despite the benefits that PC provides from a patient, family and quality of care standpoint, several barriers and disparities exist.

Addressing Challenges in Antibiotic Access: Barriers, Implications and Strategies for Solution.

Antimicrobial resistance (AMR) poses a significant threat to global public health, disproportionately affecting low- and middle-income countries (LMICs). While excessive antibiotic use is often discussed, the issue of access to antibiotics demands attention. This viewpoint explores the multidimensional nature of the issue of access to antibiotics.

Observation of the decay.

Using proton-proton collision data corresponding to an integrated luminosity of collected by the CMS experiment at , the decay is observed for the first time, with a statistical significance exceeding 5 standard deviations. The relative branching fraction, with respect to the decay, is measured to be , where the first uncertainty is statistical, the second is systematic, and the third is related to the uncertainties in and .

Antimicrobial drug pricing.

Despite the constant development of antimicrobial resistance (AMR), few new antimicrobials are currently becoming available clinically. Alternative approaches, such as different mechanisms to fund their use, are being explored to encourage development of new antimicrobials.

A systematic review of antibiotic drug shortages and the strategies employed for managing these shortages.

Background: There is a need to examine the impact of increasingly prevalent antibiotic shortages on patient outcomes and on the emergence and spread of antimicrobial resistance.

Objectives: To: (1) assess patterns and causes of shortages; (2) investigate the effect of shortages on health systems and patient outcomes; and (3) identify strategies for forecasting and managing shortages.

Data Sources: PubMed/MEDLINE, EMBASE, Scopus, and Web of Science.

Improvement in Adverse Drug Reaction (ADR) Knowledge: A Pre- and Post-video Intervention Study Among Doctors.

Background Adverse drug reactions (ADRs) represent a significant public health concern, contributing to mortality, morbidity, and healthcare costs worldwide. Healthcare practitioners especially doctors play a vital role in identifying and reporting ADR. This study investigates the prevalence of knowledge regarding ADR among doctors and enhances it with educational intervention.

Clinical pharmacokinetics of antimicrobials in critical care: a narrative review.

Introduction: The management of critically ill septic patients presents considerable challenges due to multifaceted physiological alterations. Rapid changes such as fluid shifts, hyperdynamic states, and altered renal clearance often require special attention for better clinical outcomes. Vital organ dysfunction, with or without MODS, often necessitates supportive management like RRT, ventilatory support, and ECMO.

Strengthening primary health care through community health workers in South Asia.

Unlabelled: The growing health challenges in South Asia require further adaptations of community health worker (CHW) programs as a key element of primary health care (PHC). This paper provides a comparative analysis of CHW programs in five countries (Bangladesh, India, Nepal, Pakistan, and Sri Lanka), examines successes and challenges, and suggests reforms to better ensure highly performing CHW programs. To examine CHW programs in the region, we conducted a narrative review of the peer-reviewed and grey literatures, as well as eliciting opinions from experts.