Primordial germ cells (PGCs) are the foundational cells that develop into gametes, essential for passing genetic information to offspring, making their study important in reproductive biology.
PGCs originate away from the gonads, migrating through various tissues to form sex-specific reproductive organs, which has led to extensive research on their migratory behavior and tissue interactions.
This review highlights the impact of the mechanical environment on PGC migration and adaption, suggesting that physical forces play a significant role in regulating their development and fate in the germline.