Absolute counts of peripheral blood leukocyte subpopulations in intraabdominal sepsis and pneumonia-derived sepsis: a pilot study.

The leading pathophysiological changes during sepsis include systemic abnormalities in the immune response. Due to the general character of these disturbances, sepsis is usually studied as a homogenous clinical condition. We aimed to compare the immune response in intraabdominal sepsis (IAS) and pneumonia-derived sepsis (PDS).

Sepsis immunopathology: perspectives of monitoring and modulation of the immune disturbances.

Septic syndromes are the main cause of death in the intensive care units and although the mortality rates is slowly decreasing, the occurrence of the disease has been increasing. The pathogenesis of sepsis includes countless disturbances of the host immune system starting with a harmful, infection-triggered exaggerated inflammatory cascade, followed by the development of an immunoparalysis state. The latter contributes to the failure in pathogen eradication and leads to secondary infections, which are often the cause of fatal complications.

[Infection with multidrug-resistant pathogens].

Background: Intensive therapy units are the places where pathogens can easily spread. Improper antibiotic therapy contributes to the selection of new strains called multidrug-resistant, extensively drug-resistant or pandrug-resistant. For ITU patients, such pathogens are particularly dangerous.