Synthesis and antibacterial properties of 1,2,3-aryl-1,2,3,4-tetrahydropyrimido[4,5-d]pyrimidine derivatives.

The 1,2,3-aryl-1,2,3,4-tetrahydropyrimido[4,5-d]pyrimidine derivatives have been synthesized and evaluated as antibacterial agents. The X-ray crystallography study has been undertaken to confirm structure of 2-(4-chlorophenyl)-,1 3-di-(4-methoxyphenyl)-5-methyl-7-phenyl- ,2,3,4-tetrahydropyrimido[4,5-d]pyrimidine. The antibacterial properties were tested using six selected strains by comparing changes of chemical structures with growth of biological activity.