Publications by authors named "Malgorzata Muzalewska"
Article Synopsis
- - A chitosan-based thermosensitive hydrogel (CH) enriched with hydroxyapatite (HAp) and poly(lactic acid) (PLDLLA) was developed to promote bone regeneration while exhibiting antimicrobial properties.
- - The modified hydrogels showed enhanced mechanical strength and confirmed non-cytotoxicity in tests with osteoblast-like cells, making them suitable for medical applications.
- - A clinical trial demonstrated the hydrogel's effectiveness in treating chronic inflammation in dental tissues, highlighting its safety and bone-forming capabilities through detailed analysis of pre- and post-surgery imaging.
This study details the design, fabrication, clinical trials' evaluation, and analysis after the clinical application of 3D-printed bone reconstruction implants made of nHAp@PLDLLA [nanohydroxyapatite@poly(L-lactide--D,L-lactide)] biomaterial. The 3D-printed formulations have been tested as bone reconstruction in 3 different medical cases, including frontal lobe, mandibular bone, and cleft palate reconstructions. Replacing one of the implants after 6 months provided a unique opportunity to evaluate the post-surgical implant obtained from a human patient.
View Article and Find Full Text PDFBiodegradable craniofacial and cranial implants are a new aspect in terms of reducing potential complications, especially in the long term after surgery. They are also an important contribution in the field of surgical reconstructions for children, for whom it is important to restore natural bone in a relatively short time, due to the continuous growth of bones. The aim of this study was to verify the impact of the technology on biodegradability and to estimate the risk of inappropriate implant resorption time, which is an important aspect necessary to select prototypes of implants for in vivo testing.
View Article and Find Full Text PDFThe exact causes of failure of anterior cruciate ligament (ACL) reconstruction are still unknown. A key to successful ACL reconstruction is the prevention of bone tunnel enlargement (BTE). In this study, a new strategy to improve the outcome of ACL reconstruction was analyzed using a bioresorbable polylactide (PLA) stent as a catalyst for the healing process.
View Article and Find Full Text PDFBackground: In various Achilles tendon disorders, little attention is paid to the bone environment at the tendon insertion sites. The aim of the present study was to assess the calcaneal bone structure in Achilles tendon disorders using computed tomography (CT).
Methods: This study included 31 male patients diagnosed with various Achilles disorders, including episodes of tendon rupture (TR), conservatively treated tendinopathy (TP), and critical-stage Achilles TP treated with endoscopic surgery (TS).