The RELIEF study: Tolerability and efficacy of preservative-free latanoprost in the treatment of glaucoma or ocular hypertension.

Purpose:: To assess tolerability and efficacy following a switch from benzalkonium chloride-latanoprost to preservative-free latanoprost in patients with glaucoma or ocular hypertension.

Methods:: A total of 140 patients with glaucoma or ocular hypertension controlled with benzalkonium chloride-latanoprost for at least 3 months were switched to treatment with preservative-free latanoprost. Assessments were made on days 15, 45, and 90 (D15, D45, and D90) and included best-corrected visual acuity, intraocular pressure, slit lamp examination, fluorescein staining, tear film break-up time, patient symptom evaluation, and subjective estimation of tolerability.

A comparison of intraocular pressure values obtained using a Goldmann applanation tonometer and a handheld version of applanation resonance tonometer: A preliminary report.

Background: Despite the development of various methods of intraocular pressure (IOP) measurement, Goldmann applanation tonometry (GAT) is still the most popular. The measurement using GAT depends on the biomechanical properties of the cornea, such as the thickness, the radius of curvature, as well as the amount of the fluorescein used.

Objectives: The aim of the study was to compare IOP values measured by GAT with those measured by applanation resonance tonometry (ART).

Comparison of Visual Field Measurement with Heidelberg Edge Perimeter and Humphrey Visual Field Analyzer in Patients with Ocular Hypertension.

Background: Glaucoma is a group of eye diseases which result in damage to the optic nerve and vision loss. The most important examination in glaucoma patients is visual field assessment. One of the newer perimeters is Heidelberg Edge Perimeter (HEP).

Heidelberg Edge Perimeter: The New Method of Perimetry.

Glaucoma is an optic nerve neuropathy associated with progressive visual field loss. One of the most frequent eye diseases these days, it is believed to have affected 60 million people worldwide in 2014. Various visual field examination methods are known, from the confrontational test to kinetic and static perimetry.

The presence of eye defects in patients with Turner syndrome is irrespective of their karyotype.

Objective: Published data on eye disorders in patients with Turner syndrome (TS) are limited. We aimed to evaluate the prevalence of eye disorders in patients with TS and assess the association with patient karyotype.

Design: Cross-sectional, observational study.

Using Spectralis and Stratus optical coherence tomography devices to analyze the retinal nerve fiber layer in patients with open-angle glaucoma - preliminary report.

Background: During the study at the Ophthalmology Clinic of Wroclaw Medical University retinal nerve fiber layer (RNFL) thickness was examined in 35 patients with open-angle glaucoma.

Objectives: The aim of the study was to analyse RNFL thickness measurements by 2 different optical coherence tomography (OCT) devices.

Material And Methods: The study group consisted of 35 patients with open-angle glaucoma (aged 48-76 years, including 20 women and 15 men - 70 eyes) with intraocular pressure below 19 mm Hg, treated pharmacologically.

Heidelberg edge perimeter employment in glaucoma diagnosis--preliminary report.

In recent years, the authors have seen huge progress in the diagnosis of eye diseases. One of the new diagnostic devices is HEP (Heidelberg Edge Perimeter) - for early diagnosis of glaucoma and its progression. It combines visual field test and HRT (Heidelberg Retina Tomograph), which allows authors to obtain the image of the mutual relation between the structure and the function of the sight organ.

[Leber's hereditary optic neuropathy--two case reports].

Aim: The aim of the article is to present 2 cases of LHON revealed in cousins (patients' mothers were sisters).

Material And Methods: They were both diagnosed in the Molecular Medicine Faculty and Department of Ophthalmology, Medical University of Wrocław.

Results: Three of the most popular mutations characteristic for Leber's hereditary optic neuropathy were negative in both patients.

Intraocular pressure and ocular hemodynamics in patients with primary open-angle glaucoma treated with the combination of morning dosing of bimatoprost and dorzolamide hydrochloride.

Aims: This prospective, multicenter, single-masked study evaluated the additive effect of dorzolamide hydrochloride 2% on the diurnal intraocular pressure (IOP) curve and retinal and retrobulbar hemodynamics in patients with primary open-angle glaucoma (POAG) treated with morning-dosed bimatoprost 0.03%.

Methods: Eighty-nine patients (aged, 60.

[Influence of chronic exposure to heavy metals on eyesight].

Purpose: The aim of the study was to investigate relationship between chronic occupational exposure to heavy metals and eyesight, with particular lead influence.

Material And Methods: The experimental group was composed of 120 workers of Copper Steelwork Plant "Legnica", divided into 2 groups, based on the degree and period of exposure to heavy metals. 75 men hired in direct production with work residency of 7 to 34 years (mean 21.

[Diagnostic difficulties in differentiating of arteriovenous fistula -- case report].

Arteriovenous carotid-cavernous fistula is an abnormal connection between the dural branches of carotid artery or vertebral artery and the dural sinuses. Its clinical manifestations can resemble the crucial signs of thyroid orbitopathy, an inflammatory disorder of the orbit associated with Graves' disease. Therefore, differential diagnosis of thyroid orbitopathy and the congestion of the orbit seen in arteriovenous fistula is often clinically and radiologically confused.

[Coexistence of Alzheimer's disease with pseudoexfoliation syndrome PEX].

Alzheimer disease is a type of cerebral amyloidosis, which is most frequently recognized after the age of 80. In pathophysiology of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and age-related cataract changes in protein aggregation play important role, for that reason they form common group of diseases, called conformational diseases. Patients with Alzheimer disease have more common pseudoexfoliation syndrome (PEX), characterized by the accumulation of an abnormal pathognomonic material in the anterior segment of the eye.

Retinal antigens are recognized by antibodies present in sera of patients with multiple sclerosis.

Multiple sclerosis (MS) is frequently accompanied by visual symptoms including those related to retinal disorders. Since they may be a consequence of an autoimmune reaction, we examined whether sera of patients with diagnosed MS and changes in visual-evoked potentials contain antibodies against retinal antigens (retAgs). Immunoblot analysis revealed that MS sera recognized mainly a 46-kD antigen, a 41-kD antigen, retinal arrestin, to a smaller extent also 70-, 56-, 43-, and 36-kD proteins.

[The role of color vision disturbances in diagnostics of early diabetic retinopathy].

Purpose: The evaluations of color vision sensitivity in children with type I diabetes mellitus without retinopathy.

Material And Method: We examined 96 young patients. They was divided into three groups: I: 35 children from 7 to 16 years old with insulin-dependent diabetes mellitus duration of 1-8 years, II: 30 children with type I diabetes lasting more then 8 years, III--31 non-diabetic subjects as a control-matched for age and sex, without visual or systemic symptoms.