Oncogenic BRAF mutations and p16 expression in melanocytic nevi and melanoma in the Polish population.

Introduction: Twenty-five - fifty percent of skin melanomas arise from nevi. Melanocyte proliferation is activated by , then is arrested, but single nevi transform to melanomas. p16 controls arrest, and p16 loss may promote transformation.

Febrile neutropenia in a metastatic melanoma patient treated with ipilimumab - case report.

Background: Ipilimumab is a fully human monoclonal antibody (mAb) targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4). Ipilimumab is currently approved in the U.S.

Resistance to vemurafenib can be reversible after treatment interruption: a case report of a metastatic melanoma patient.

About 40% to 60% of melanomas present BRAF mutation. Selective BRAF inhibitors such as vemurafenib and dabrafenib are currently approved for the treatment of advanced melanoma patients with BRAF mutation. The treatment-induced tumor regression occurs in the majority of patients; however, acquired resistance to BRAF inhibitors is observed in most of the patients after 6 to 7 months.

Skin pH is lower in type 1 diabetes subjects and is related to glycemic control of the disease.

Background: Diabetes is a systemic disease affecting many organs, including skin. Skin may reflect the condition of internal organs. The aim of our study was to measure skin pH in type 1 diabetes mellitus (T1DM) patients and in healthy controls and to evaluate the association between metabolic control of diabetes and skin acidity in T1DM patients.

Acne inversa goes an extra mile than hidradenitis suppurativa.

Acne inversa (AI, hidradenitis suppurativa, Velpeau's disease, Verneuil's disease) is a severe, chronic inflammatory dermatosis of unknown etiology, detected on the basis of clinical symptoms more frequently in women than in men. Purulent lesions in the form of nodules and inflammatory tumors, fistulas and scars are present in the areas with hair follicles and apocrine glands, most commonly on the armpits, groin, around the anus and pubic region. Acne inversa can lead to physical and mental disorders.

Co-occurrence of acanthosis nigricans and bladder adenocarcinoma - case report.

Acanthosis nigricans (AN) is characterized by the occurrence of symmetrical velvety hyperpigmented plaques that can be observed in each location on the skin. However, the lesions are most frequently located in the axillary, inguinal and nuchal areas. Primarily, the lesions appear as hyperpigmented focuses which later transform into papillary lesions.

Basal cell carcinoma - diagnosis.

Basal cell carcinoma is the most common skin cancer in the Caucasian population. The cancer arises in sun exposed areas of the skin. The incidence of morbidity is high and it is still growing.

New therapeutic options in systemic treatment of advanced cutaneous melanoma.

Introduction: For many years systemic treatment of advanced/metastatic melanoma has been based on chemotherapy or immunotherapy. However, even very toxic regimens (e.g.

Progress in the treatment of bone metastases in cancer patients.

Introduction: Bone metastases are a frequent complication of cancer, occurring in up to 70% of patients with advanced breast or prostate cancer. Skeletal-related events involving pathological fractures, spinal cord compression and a need for surgery/radiotherapy, which are frequently observed in cancer patients with bone metastases have a detrimental effect on patients' survival and quality of life. Therefore, prevention of skeletal-related events is a crucial element in cancer treatment.

The 32nd Annual Meeting of German Society of Immunology. 26 - 29 September 2001.

The 32nd Annual Meeting of German Society of Immunology (DGfi) was held in Dresden on 26 - 29 September 2001. The philosophy of the meeting was 'to throw some light on the progress that had been made in transferring basic immunological research into clinical application'. More than 500 abstracts were submitted.

3rd international symposium on genetic anticancer agents.

The 3rd International Symposium on Genetic Anticancer Agents was an initiative of NDDO Research Foundation, which is an internationally operating organisation exclusively devoted to the research and development of new strategies for the treatment of cancer. The meeting focused on the preclinical and clinical development of various genetic agents for cancer treatment. Leading world experts came to Amsterdam to present recent results of their highly advanced research and to discuss novel approaches to cancer treatment.