Biocompatibility of Hemodialysis.

This study was designed to investigate the biocompatibility of hemodialysis procedures, largely depending on the contact of patient's blood with the dialysis membranes. We addressed the issue by comparing the content of the proteolytic enzymes collagenase and cathepsin B and that of neutrophil myeloperoxidase (MPO) and C-reactive protein (CRP) in the blood before and after a single session treatment and a full course of successive 8-week-long therapies with three types of hemodialysis: low-flux (lfHD), high-flux (hfHD), and post-dilution hemodiafiltration (HDF). The study included 19 patients with chronic nephropathy.

Lean Tissue Index and Body Cell Mass Can Be Predictors of Low Free Testosterone Levels in Men on Hemodialysis.

Objective: Testosterone deficiency is a common disorder among men treated with hemodialysis. The aim of our study was to evaluate the relationship between free testosterone levels and body composition, biochemical markers of nutritional status, and inflammation in men on hemodialysis.

Design: Prospective analysis of men treated with hemodialysis for more than 3 months in one hemodialysis center.

Protein-Bound Solute Clearance During Hemodialysis.

Indoxyl sulfate (IS) and p-cresol sulfate (p-CS) are protein-bound solutes that accumulate in the blood serum in chronic kidney disease and have a detrimental effect on the kidney and other organs' function. This study seeks to define the effectiveness of IS and p-CS clearance after single dialysis sessions and after 8-week-long cycles of hemodialysis using the following different dialysis modalities in succession: low-flux hemodialysis (lfHD), high-flux hemodialysis (hfHD), and post-dilution hemodiafiltration (HDF). We also investigated to what extent IS and p-CS serum content would associate with some other biochemical indices in patients with chronic kidney diseases.

Protein-bound uremic toxins - biological effects and impact on morbidity in patients with chronic kidney disease.

Cardiovascular complications are the main cause of increased mortality in patients with chronic kidney disease. Besides traditional risk factors, accumulated uremic toxins contribute to the accelerated atherosclerosis, which is accompanied by the progression of chronic kidney disease. Increased clearance of toxins with low molecular weight does not significantly improve survival of hemodialysis patients, and therefore the role and influence of other toxins, including protein-bound solutes (PBS) is intensively investigated.

Is Free Testosterone Concentration a Prognostic Factor of Survival in Chronic Renal Failure (CRF)?

Background: Lowered testosterone level in CRF patients is associated with elevated risk of death due to cardiovascular reasons, and is influenced by many factors, including acid-base balance disorders.

Aims: evaluation of testoste-rone concentration (TT) and free testosterone concentration (fT) in pre-dialysis and dialysis patients; assessment of TT and fT relationships with biochemical parameters; evaluation of prognostic importance of TT and fT in predicting patient survival.

Material And Methods: 4 groups of men: 14 - on hemodialysis (HD), 13 - on peritoneal dialysis (PD), 9 - with chronic renal failure (CRF) and 8 - healthy (CG), aged 56±17, 53±15, 68±12, 43±10 years, respectively.

[In the search for effective and safe dose of amikacin in patients with chronic kidney disease].

Unlabelled: The aim of the study was to asses safe and effective amikacin (AMK) doses in patients with different stages of chronic kidney disease.

Material And Methods: The study included 25 patients, among them was 12 (48%) men and 13 (52%) women, aged 73.1 +/- 11.

[How to safely and effectively administer aminoglycoside antibiotics].

Aminoglycoside antibiotics (AA) are drugs with a narrow therapeutic window and cause severe and often irreversible side effects. They are often used in combination with other antibiotics to treat serious infections caused by aerobic Gram-negative rods. Irreversibly combined with rRNA (16S) subunit of the bacterial 30S ribosomal aminoacyl acceptor site interaction disrupting codon (mRNA) of the anticodon (in tRNA).

Homeostatic model assessment indices in evaluation of insulin resistance and secretion in hemodialysis patients.

Background: Some previous observations suggest that insulin resistance and glucose metabolism disturbances are frequent complications of chronic kidney disease. However, there are no conclusive studies on other indices of the effectiveness of insulin action in end-stage renal disease (ESRD) patients, including chronically hemodialysed (HD) ones.

Material And Methods: The groups comprised 33 non-diabetic ESRD hemodialysed patients and 33 healthy controls matched for age, sex, and body mass index (BMI).

[Rapid course of Churge-Strauss syndrome--since appearance of asthma till development of renal failure and neurological complication].

Churge-Strauss Syndrome belongs to systematic, necrotic inflammation of medium and small vessels diseases. In this paper it is presented a case of 63 years old man with benign asthma, recognized six month earlier. Later occurs fever, difficulties with breathing, cough, fast progressing paresis of tree limbs, thinning and nephrotic syndrome with fast growing renal failure.

[Metoclopramide test in the patients with hyperprolactinemia due to end-stage renal failure].

Unlabelled: Evaluation of metoclopramide (MTC) test values in end-stage renal disease patients undergoing hemodialysis with different level of hyperprolactinemia was aim of the study. Clinical value of application of the MTC test and influence of different laboratory and clinical factors including erytropoietin treatment were examined. Sixty-eight hemodialysed patients (31 male and 37 female) aged 20-74 yr.

Carpal tunnel syndrome in dialysed patients - interdisciplinary experiences.

This paper presents an analysis of patients in hemodialysis with carpal tunnel syndrome. The pathogenesis and diagnostics of the syndrome are discussed, as well as treatment outcomes. The authors argue that treatment methods to avoid amyloidosis caused by dialysis should be introduced as standard procedure, especially in older patients at high risk for amyloidosis.

[Hepatorenal syndrome. Cases report].

The hepatorenal syndrome is defined as renal failure in patients with severe liver disease. It may be diagnosed by exclusion of other potential factors which may cause renal failure, such as hypovolaemia, nephrotoxic drugs and severe bacterial infection. Liver transplantation is the target treatment leading to recovery of renal function.

Serum growth factors in hemodialyzed patients.

The contact of chronic hemodialysis patients' blood with components of extracorporeal circulation leads to mobilization of several systemic reactions. The purpose of this study was to determine the activity of transforming growth factor (TGF-beta1) and platelet derived growth factor (PDGF) in serum of patients on long-term hemodialysis program and to compare these results with ones obtained in healthy volunteers. Twenty-five patients on dialysis carried out on polysulfone membrane dialyzer, and 16 patients on dialysis with the used of cuprophan membrane dialyzer on long-term hemodialysis program participated in the study.