Publications by authors named "Malgorzata A Bagnucka"
The outermost layer of centrosomes, called pericentriolar material (PCM), organizes microtubules for mitotic spindle assembly. The molecular interactions that enable PCM to assemble and resist external forces are poorly understood. Here, we use crosslinking mass spectrometry (XL-MS) to analyze PLK-1-potentiated multimerization of SPD-5, the main PCM scaffold protein in C.
View Article and Find Full Text PDFDuring mitotic spindle assembly, microtubules generate tensile stresses on pericentriolar material (PCM), the outermost layer of centrosomes. The molecular interactions that enable PCM to assemble rapidly and resist external forces are unknown. Here we use cross-linking mass spectrometry to identify interactions underlying supramolecular assembly of SPD-5, the main PCM scaffold protein in .
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- Tick-borne encephalitis virus (TBEV) causes severe brain inflammation, primarily in northern Asia and Europe, and can lead to chronic illness or death; climate change is expanding its reach.
- Interferon-induced transmembrane proteins (IFITMs), particularly IFITM3, are crucial for inhibiting TBEV infection and preventing cell death caused by the virus, with studies employing CRISPR-Cas9 methods confirming their protective roles.
- Despite their protective effects, TBEV may partially evade IFITM suppression during high-density infections by spreading directly between cells, highlighting the need for further research into antiviral strategies and innate immune responses.