Publications by authors named "Malen Ea"
We recently characterized the potent antiplasmodial activity of the aggregated protein dye YAT2150, whose presumed mode of action is the inhibition of protein aggregation in the malaria parasite. Using single-dose and ramping methods, assays were done to select Plasmodium falciparum parasites resistant to YAT2150 concentrations ranging from 3× to 0.25× the in vitro IC of the compound (in the two-digit nM range) and performed a cross-resistance assessment in P.
View Article and Find Full Text PDFBackground: Mosquitoes are important drivers of infectious diseases transmission, with Anopheles mosquitoes being responsible of malaria transmission. In Cambodia, where malaria is prevalent in forested regions, understanding the ecology of these vectors is crucial. This study aimed to investigate the abundance, distribution, seasonal patterns, biting behaviour of Anopheles mosquitoes, and prevalence of Plasmodium, in Mondulkiri province, Northeastern Cambodia.
View Article and Find Full Text PDFArticle Synopsis
- The Great Mekong Subregion has seen significant reductions in malaria cases, yet certain populations, particularly forest workers and migrants, continue to contribute to ongoing transmission hotspots.
- The study involved tracking the movements of male forest goers over two 28-day periods by combining GPS data, questionnaires, and health exams to assess their exposure to malaria.
- Findings indicated that malaria risk was higher in villages with less forest cover, suggesting that proximity to forest does not necessarily increase malaria risk, and that there was a notable discrepancy between GPS tracking and self-reported movement data.