Evaluating the Toxocara cati extract as a therapeutic agent for allergic airway inflammation.

Background: The hygiene hypothesis suggests that early life exposure to helminth infections can reduce hypersensitivity in the immune system.

Objective: The present study aims to evaluate the effects of Toxocara cati (T. cati) somatic products on allergic airway inflammation.

Association between proliferation status of infected and non-infected mononuclear cells with tissue lesions in acute bovine theileriosis.

Tropical or Mediterranean theileriosis in dairy cattle is widely distributed in many tropical regions of the world. The purpose of this study was to evaluate the proliferation status of mononuclear cells infected with schizonts in different tissues and its relationship with the pathogenesis of the parasite in cattle by histopathology, immuno-histochemistry and polymerase chain reaction (PCR). Blood and tissue samples of eight Holstein cattle that had been lost due to theileriosis and eight healthy slaughtered cattle of the same breed were collected as a control group after necropsy.

The effects of Quercetin supplementation on cardiometabolic outcomes: An umbrella review of meta-analyses of randomized controlled trials.

Background: Quercetin is a bioactive flavonoid, but the effect of it on cardiometabolic factors has remained uncertain and previous findings from meta-analyses have been controversial.

Objective: To provide an overview of the effects of Quercetin on cardiometabolic factors based on meta-analyses of randomized controlled trials (RCTs).

Method: MEDLINE, SciVerse Scopus, and Clarivate Analytics Web of Science databases were searched to identify eligible publications.

Ameliorative effects of crocin against electromagnetic field-induced oxidative stress and liver and kidney injuries in mice.

Objective: The current study's goal was to examine how crocin affects organ damage such as damage to the kidney and liver in mice treated by 2100 MHz Electro Magnetic Field.

Materials And Methods: The liver and kidneys of mice exposed to EMFs were used in this study to examine how crocin affected them. 24 male NMARI mice were randomly divided into 4 groups: EMF group (2100 MHZ); Crocin (Cr) group (50 mg/kg); EMF+Crocin group (2100 MHZ+50 mg/kg), and control group.

The mouse model of chronic asthma: Airway remodelling and disease exacerbation by somatic antigen of Echinococcus granulosus.

There is now sufficient evidence to support an inverse association between helminth infection and secreted products with allergic/autoimmune disorders. Accordingly, several experimental studies have shown that Echinococcus granulosus infection and hydatid cyst compounds are able to suppress immune responses in allergic airway inflammation. This is the first study on effects of somatic antigens of E.

Prevalence of celiac disease and its related factors in children aged 2-6 years old: A case-control study.

Celiac disease (CD) is an immune-genetic disorder associated with the small intestine. The aim of this study was to determine the prevalence of CD and its related factors in children aged 2-6 years in southeastern Iran. In the present case-control research, the study groups were selected by convenience sampling method in Zahedan city, Sistan-and-Baluchestan province, southeastern Iran, from January 2021 till January 2022.

Pregabalin in patients with post-traumatic peripheral neuropathic pain: A meta-analysis of randomized controlled trials.

Objective: The aim of the study was to investigate the safety and efficacy of pregabalin versus placebo in post-traumatic peripheral neuropathic pain (PTNP).

Methods: PubMed, Cochrane Library, Web of Science, and Google Scholar were searched for relevant evidence up to January 2022. The Cochran tool was used to assess the quality of randomized clinical trials (RCTs).

Correlation between adiponectin rs2241766 and rs266729 polymorphisms and risk of papillary thyroid cancer.

About 60-80% of thyroid cancer (TC) cases are papillary thyroid cancer (PTC). Studies have shown that serum adiponectin levels are inversely related to the risk of TC and PTC. Aim of the present study was to evaluate the association between adiponectin rs2241766 and rs266729 polymorphisms and risk of PTC.

Effect of intermittent fasting on saving zone of stasis in burn wounds in rats.

Background: Intermittent Fasting (IF) has proved to have various positive effects on life span, diseases, and healing of tissues in rodents. We evaluated the protective effect of fasting in maintaining the ischemic zones in burn wounds.

Methods: In this study, 20 rats were divided into two groups where the IF rats were deprived of food for three months.

Exacerbation of allergic asthma by somatic antigen of Echinococcus granulosus in allergic airway inflammation in BALB/c mice.

Background: There is ample evidence demonstrating a reverse relationship between helminth infection and immune-mediated diseases. Accordingly, several studies have shown that Echinococcus granulosus infection and hydatid cyst compounds are able to suppress immune responses in allergic airway inflammation. Previous studies have documented the ability of hydatid cysts to suppress aberrant Th2 immune response in a mouse model of allergic asthma.

Robust clustering of COVID-19 cases across U.S. counties using mixtures of asymmetric time series models with time varying and freely indexed covariates.

In this paper, we develop a mixture of autoregressive (MoAR) process model with time varying and freely indexed covariates under the flexible class of two-piece distributions using the scale mixtures of normal (TP-SMN) family. This novel family of time series (TP-SMN-MoAR) models was used to examine flexible and robust clustering of reported cases of Covid-19 across 313 counties in the U.S.

A Bayesian approach on the two-piece scale mixtures of normal homoscedastic nonlinear regression models.

In this application note paper, we propose and examine the performance of a Bayesian approach for a homoscedastic nonlinear regression () model assuming errors with two-piece scale mixtures of normal (-) distributions. The - is a large family of distributions, covering both symmetrical/ asymmetrical distributions as well as light/heavy tailed distributions, and provides an alternative to another well-known family of distributions, called scale mixtures of skew-normal distributions. The proposed family and Bayesian approach provides considerable flexibility and advantages for modelling in different practical settings.

Time series modelling to forecast the confirmed and recovered cases of COVID-19.

Coronaviruses are enveloped RNA viruses from the Coronaviridae family affecting neurological, gastrointestinal, hepatic and respiratory systems. In late 2019 a new member of this family belonging to the Betacoronavirus genera (referred to as COVID-19) originated and spread quickly across the world calling for strict containment plans and policies. In most countries in the world, the outbreak of the disease has been serious and the number of confirmed COVID-19 cases has increased daily, while, fortunately the recovered COVID-19 cases have also increased.

Modeling and forecasting the spread and death rate of coronavirus (COVID-19) in the world using time series models.

Coronaviruses are a huge family of viruses that affect neurological, gastrointestinal, hepatic and respiratory systems. The numbers of confirmed cases are increased daily in different countries, especially in Unites State America, Spain, Italy, Germany, China, Iran, South Korea and others. The spread of the COVID-19 has many dangers and needs strict special plans and policies.

Evaluation of the effect of Toxocara cati infection in the mouse model of allergic asthma: Exacerbation of allergic asthma symptoms and Th2 types of response.

Toxocariasis is considered a neglected disease despite the importance of Toxocara spp. infections for human health and is little recognized as a significant problem by public health institutions in developing countries. Epidemiological studies suggest that infection with Toxocara cati contributes to the development of allergic asthma.

Time series modelling to forecast the confirmed and recovered cases of COVID-19.

Coronaviruses are enveloped RNA viruses from the Coronaviridae family affecting neurological, gastrointestinal, hepatic and respiratory systems. In late 2019 a new member of this family belonging to the Betacoronavirus genera (referred to as COVID-19) originated and spread quickly across the world calling for strict containment plans and policies. In most countries in the world, the outbreak of the disease has been serious and the number of confirmed COVID-19 cases has increased daily, while, fortunately the recovered COVID-19 cases have also increased.

Effect of structural distortions on articular cartilage permeability under large deformations.

The permeability of articular cartilage has a key role in load support and lubrication in diarthrodial joints. The microstructural rearrangement and consequent alteration in permeability caused by the large deformations undergone by cartilage have been previously modelled with a multi-scale approach. At the microscopic scale, the tissue is regarded as a homogeneous fluid-filled proteoglycan matrix reinforced by collagen fibres.

A survey on Toxocara cati eggs on the hair of stray cats: A potential risk factor for human toxocariasis in Northeastern Iran.

The objective of this study was to investigate the presence of Toxocara eggs on the hair of stray cats. The total number of stray cats trapped and included in the trial was 167 that were collected weekly from different residential areas of Mashhad, in northeastern Iran, from November 2016 to December 2017. Among the 167 cats, 18 (10.

Orthotropic hydraulic permeability of arrays of parallel cylinders.

Approximate analytical methods are presented to calculate the overall orthotropic hydraulic permeability of a flow with low Reynolds number, passing through a bundle of parallel circular cylinders. Two particular distributions are considered: (i) arrays with ordered rectangular lattices and (ii) irregular nonrandom distributions for which the unit cell cross sections are elliptical. The standard unit cell models, originally developed by Happel and Kuwabara for a random distribution of cylinders, are adapted to the case of nonrandom distributions.

Co-delivery of Dual Toll-Like Receptor Agonists and Antigen in Poly(Lactic-Co-Glycolic) Acid/Polyethylenimine Cationic Hybrid Nanoparticles Promote Efficient Immune Responses.

Strategies to design delivery vehicles are critical in modern vaccine-adjuvant development. Nanoparticles (NPs) encapsulating antigen(s) and adjuvant(s) are promising vehicles to deliver antigen(s) and adjuvant(s) to antigen-presenting cells (APCs), allowing optimal immune responses against a specific pathogen. In this study, we developed a novel adjuvant delivery approach for induction of efficient immune responses.

Relationships between Oxidative Stress, Liver, and Erythrocyte Injury, Trace Elements and Parasite Burden in Sheep Naturally Infected with .

Background: The aim of this study was to investigate the role of oxidative stress in the pathology of ovine dicrocoeliasis.

Methods: During Dec 2013 - Oct 2014, seventy-two sheep (1-3 years) with liver dicrocoeliasis along with 47 healthy sheep were selected from animals admitted for slaughtering at slaughterhouse located in Neyshabour, Razavi Khorasan Province, Iran.

Results: In comparison to healthy control, the malondialdehyde (MDA) level and serum total antioxidant capacity were significantly higher in the parasitized group (<0.

Somatic extracts of Marshallagia marshalli downregulate the Th2 associated immune responses in ovalbumin-induced airway inflammation in BALB/c mice.

Background: Recently the role of gastrointestinal nematodes in modulating the immune responses in inflammatory and immune-mediated conditions such as allergy and autoimmune diseases has been introduced. This is mainly due to the suppressive effects of somatic and excretory secretory (ES) products of nematodes on the immune responses. In this study, we evaluated the immunomodulatory potentials of somatic products of Marshallagia marshalli, a gastrointestinal nematodes of sheep, to suppress the immune-mediated responses in a murine model of allergic airway inflammation.

Anti-inflammatory Potentials of Excretory/Secretory (ES) and Somatic Products of on Allergic Airway Inflammation in BALB/c Mice.

Background: Inverse relationship between helminths infection and immune-mediated diseases has inspired researchers to investigate therapeutic potential of helminths in allergic asthma. Helminth unique ability to induce immunoregulatory responses has already been documented in several experimental studies. This study was designed to investigate whether excretory/secretory (ES) and somatic products of modulate the development of ovalbumin-induced airway inflammation in a mouse model.

Parasitic Burdens, Egg Output, Hemathologic, and Biochemical Changes in Naturally Infected Lambs with .

Background: We investigated the variations of heamathologic and biochemical parameters with different parasitic burdens and the correlation between fecal egg counts and fluke number in livers of sheep naturally infected with .

Methods: In order to detect excretion of eggs, fecal samples from 120 sheep of different age groups were collected individually at slaughterhouse in Neyshabur County in Razavi Khorasan Province during December 2013 - October 2014. Hematologic and blood biochemical values in 120 sheep naturally infected with were compared with equivalent values in 120 parasite-free sheep from an organically farmed flock.