Publications by authors named "Maleki Assih"
Article Synopsis
- The severity of liver disease and treatment response in hepatitis are influenced by the virus genotype, prompting a review of hepatitis virus genotypes in West Africa.
- The review identified 52 articles, revealing that hepatitis B virus (HBV) genotype E is the most prevalent (90.6%) in the region, showing low genetic diversity, while hepatitis C virus (HCV) genotypes 1 and 2 account for 96.4% of infections.
- The findings indicate a need for further research on the clinical impact of these genotypes and improved surveillance to prevent new, more dangerous strains from emerging.
Article Synopsis
- Antimalarial medications, like primaquine, can cause severe anemia in individuals with G-6-PD deficiency, which is prevalent in malaria-endemic regions like Burkina Faso.
- A systematic review analyzed existing studies to estimate the prevalence and genetic variants of G-6-PD deficiency in Burkina Faso, revealing an average prevalence of 16.6% in men and 6.5% in women.
- The review found that almost all cases (99.8%) of G-6-PD deficiency were due to the G-6-PD A- variant, and enzymatic deficiency was notably higher in males compared to females.
Article Synopsis
- This study compared the effectiveness of multiplex PCR and ELISA in detecting HBV, HCV, and HIV in blood samples from donors in Togo, using 440 samples for the analysis.
- Multiplex PCR was found to be more sensitive for detecting HBV, while ELISA was better at identifying HCV and HIV cases.
- Gender did not affect the sensitivity of either testing method, highlighting limitations in both ELISA and multiplex PCR for viral detection.
Introduction: In most developing countries, Cytomegalovirus (CMV), Epstein Barr virus (EBV) and Herpes virus 6 (HHV-6) are not diagnosed in blood donors. The aim of this study is to determine the prevalence of these viruses in blood donors from the city of Ouagadougou, Burkina Faso.
Methods: The study included 198 blood donors of the Regional Blood Transfusion Centre of Ouagadougou.
Background: Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3G (APOBEC3G) is a potent host defense factor, which interferes with HIV-1 and HBV. Our study had three objectives, to screen a population of HIV-1 infected and uninfected patients in Burkina Faso for HBV, to screen the population for APOBEC3G variants rs6001417, rs8177832, and rs35228531 previously described, and to analyze the effect of these three variants and their haplotypes on HIV-1/HBV co-infection in Burkina Faso.
Methods: HBV detection was performed on samples from HIV-1 infected and uninfected subjects using rapid detection tests and real-time PCR.
Studies on host factors, particularly the APOBEC3G gene, have previously found an association with AIDS progression in some populations and against some HIV-1 strains but not others. Our study had two main objectives: firstly, to screen a population from Burkina Faso for three variants of APOBEC3G previously described, and secondly to analyze the effect of these three variants and their haplotypes on HIV-1 infection with Circulating Recombinant Forms (CRFs) present in Burkina Faso. This case control study involved 708 seropositive and seronegative individuals.
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- This study explored the link between specific genetic variations in the renin-angiotensin system and essential hypertension in people from Burkina Faso, using a case-control design with 202 hypertensive patients and 204 matched controls.
- The research found that while two polymorphisms (AGT 235M/T and AT1R 1166A/C) showed no association with hypertension, the ACE I/D polymorphism had significantly different genotype frequencies between the groups, with the DD genotype being more prevalent in hypertensive patients.
- Key risk factors identified included the DD genotype of the ACE gene, older age, obesity, dyslipidemia, and alcohol consumption, indicating that the DD genotype is a significant predictor of hypertension susceptibility.
Objectives. In Burkina Faso, few studies reported the prevalence of HBV and HCV in the general population. This study aimed to evaluate the prevalence of hepatitis B and C viruses in the general population and to determine the most affected groups in relation to the risk factors associated with the infection.
View Article and Find Full Text PDFObjective: To assess the seasonality of the bacterial meningitis and the antibiotic resistance of incriminated bacteria over the last three years in the northern Togo.
Methods: From January 2007 to January 2010, 533 cerebrospinal fluids (CSF) samples were collected from patients suspected of meningitis in the Regional Hospital of Dapaong (northern Togo). After microscopic examination, samples were cultured for bacterial identification and antibiotic susceptibility.