Once-weekly oral doses of fluconazole 150 mg in the treatment of tinea pedis.

Seventy adult out-patients with tinea pedis participated in a multicentre open non-comparative study of the safety and efficacy of once-weekly doses of oral fluconazole 150 mg. A mean of 3 doses of fluconazole was administered; patients infected with Candida required an average of 2 doses compared to 3-4 doses in patients infected with other organisms. Clinical cure was obtained in 45 of 61 (74%) evaluable patients at the last post-treatment evaluation, with 15 patients being substantially improved and one patient failing clinically.

Once-weekly oral doses of fluconazole 150 mg in the treatment of tinea corporis/cruris and cutaneous candidiasis.

Ninety-five adult out-patients with tinea corporis and/or tinea cruris participated in a multicentre open non-comparative study investigating the safety and efficacy of 1-4 once-weekly doses of oral fluconazole 150 mg. Trichophyton rubrum was isolated most frequently (67 of 86 mycologically evaluable patients). A mean of 2.

[Rhinocerebral mycoses caused by Mucoraceae species (mucormycosis). Case report and literature review].

According to the literature and on the basis of the case reported in this paper of rhinocerebral mucoraceae mycosis we summarize the characteristic features as follows: mucoraceae--mycoses--common, but wrong term: "mucormycoses"--are a group of infections caused by members of the family mucoraceae (Mucor, Rhizomucor, Rhizopus, Absidia species)--most frequently by Rhizopus species. Primarily the fungi enter the pharynx or nose, local infections or trauma being a prerequisite. The most important predisposing factor is diabetes mellitus.

[Mycoses--a broad spectrum multi-faceted disease complex].

This article gives a survey of the most important general aspects of mycoses. This comprises their spectrum of organisms, their pathogenicity and their nosologic features. In a more detailed way, the following topical forms of infections will be discussed: Mycoses favoured by factors of civilization, survival mycoses, mycoses resulting from progress of medicine, opportunistic mycoses and mycoses associated with AIDS.

[Secondary cutaneous mycoses caused by Alternaria species].

Analysis of 2 of our own cases of cutaneous alternariosis (CA) and 31 reported cases showed this mycosis to be nosologically heterogeneous. CA may present as an endogenous, multilocular form or as an exogenous, usually localized form. In the endogenous form of CA (11 cases), infection most probably occurs via the lung by inhalation.

[Mycogenic allergies (author's transl)].

The most common causes of mycogenic allergies of the respiratory tract are cladosporium-, aspergillus-, ustilago-, monilia- and alternaria-species. On the second place follow species of epicoccum and penicillium as well a some asco- and basidiomycetes. The majority of these germs represents banal molds whose natural habitat is predominantly the soil and the vegetable kingdom.

[Animal experiments on the persorption of Candida albicans and a possible resultant immune response (author's transl)].

The aim of this study was to find out whether the saprophytic presence of abnormally high quantities of C. albicans in the digestive tract leads to the development of a) positive serological reactions to this fungus and/or b) fungaemia via persorption. The following experiments were performed with rabbits: Administration of suspensions of living or inactivated yeast cells or of starch flour by gastric tube; intradermal immunization and administration of certain antibiotics in a separate comparative series; serological, histological and/or mycological investigations in blood, urine and tissue samples.

[An evaluation of candida serology following renal transplantation and its connexion with other postoperative complications (author's transl)].

53 renal transplant recipients aged 13 to 58 years were followed up regularly clinically, microbiologically and serologically over observation periods ranging from 6 to 82 months following transplantation with a view to diagnosing mycetic complications. The only (facultative) pathogenic species found was Candida albicans. This species was isolated in every single patient, but far-reaching differences were observed with regard to the degree of form of infection in the individual person.

[Levuroses appearing in cases of severe burns].

The preconditions for the development of systemic mycoses, mainly levuroses, caused by opportunistic organisms are particularly favorable in the severely burned patients: on the one hand as a consequence of suppression of immunity, on the other hand by the overgrowth of these fungi in the digestive tract as a side-effect of the antibacterial chemotherapy which is necessary for the treatment of the original disease. Since such mycoses are usually very severe, mostly life endangering, their prophylaxis and early diagnosis are highly important. The aspects and measurements, most important in this connection, are discussed on the basis of our experience.

[How should mycoses by most effectively treated in dermatological practice?].

An appropriate antimycetic therapy in the office is based on the following prerequisites: 1. demonstration and identification or at least determination of species of the causative germ, 2. selection of an adequate antimycetic medicament with a) least possible rate of sensitisation, b) greatest possible effectiveness and c) a spectrum as restricted as possible, d) galenic preparation and e) duration of therapy depending on the clinical and histological type of the mycosis, 3.

[Etiopathogenesis and epidemiology of candidiasis and related yeast mycoses].

The clinically and histologically well differentiated clinical picture of candidosis (CA) is heterogenous with regard to etiology: Only about 95 per cents of the cases are caused by candida species, the rest by other cryptococcaceae species. Formal pathogenetically the CA may be primary as well as secondary. Which kind of pathogenicity is predominating depends first of all on the momentary ecological, civilisational and medical conditions.

[Systemic candidiasis in the severely burned patient (author's transl)].

As a result of progress in the modern treatment of burns, systemic candidosis (CA), in the sense of "surviving mycoses", has become increasingly frequent. The site of entry is not usually the wound, but the intestinal tract, which becomes overgrown by the yeasts as a consequence of the requisite therapy with antibacterial antibiotics in high dosage. Passage of the organism into the circulation occurs by persorption.

[BCG-septicemia and mucocutaneous candidiasis due to familial combined immunodeficiency (authors transl)].

The history of a patient with mucocutaneous candidiasis and BCG-septicemia is reported. Combined immunodeficiency has been diagnosed as the underlying cause. A sister of the patient died at seven months of age under similar circumstances.

[Diagnostic and therapeutic problems in lichen ruber ulcerosus].

Report on two patients with ulcerative lichen planus (l.r. u.