Primary small cell carcinoma of the breast with TTF-1 and neuroendocrine marker expressing carcinoma in situ.

Primary small cell carcinoma (SmCC) of the breast is very rare and may be difficult to distinguish from metastatic small cell carcinoma. Confident histopathological diagnosis of a primary breast SmCC requires the demonstration of an in situ component. We report a case of primary small cell carcinoma of the breast with coexisting carcinoma in situ in which the invasive carcinoma and in situ component both expressed neuroendocrine markers and Thyroid transcription factor-1 (TTF-1) by immunohistochemistry.

Reliance on hormone receptor assays of surgical specimens may compromise outcome in patients with breast cancer.

Purpose: To assess the concordance of breast cancer immunohistochemical receptor assays on core biopsy and surgical specimens.

Patients And Methods: We identified 100 patients whose core biopsy and definitive surgical specimens were processed in our hospital. New sections, with core and surgical specimens on the same slides, were stained for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2) immunohistochemistry (IHC).

Squamous cell carcinoma arising in the skin of a deltopectoral flap 27 years after pharyngeal reconstruction.

Background: Development of a second primary squamous cell carcinoma in the skin of a flap used for pharyngeal reconstruction is rare.

Methods: A case of squamous cell carcinoma is presented arising in a deltopectoral flap used to reconstruct the hypopharynx 27 years after total laryngectomy. Three previous reports found on review of the literature are summarized.