Publications by authors named "Malcolm Gp Page"
New strategies are urgently required to develop antibiotics. The siderophore uptake system has attracted considerable attention, but rational design of siderophore antibiotic conjugates requires knowledge of recognition by the cognate outer-membrane transporter. is a serious pathogen, which utilizes (pre)acinetobactin to scavenge iron from the host.
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- Ceftobiprole medocaril is a new cephalosporin antibiotic being tested for treating serious skin infections and hospital-acquired pneumonia, especially those caused by drug-resistant bacteria like MRSA.
- It effectively targets penicillin-resistant bacteria and has shown strong antibacterial activity in laboratory studies against a range of harmful Gram-positive and Gram-negative pathogens.
- Currently, it is undergoing Phase III clinical trials, with early results indicating a high cure rate and good tolerance among patients dealing with complicated skin infections and other related conditions.