Publications by authors named "Malchikova L"

J. Raven's (1992) classification was used in the treatment of patients with multiple fractures of the face associated with contusions, brain concussions, and injuries to the skull vault and base. According to this classification, all injuries of the cerebral and facial skull are classified as types I, II, and subtype Ia.

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In order to elucidate the mechanisms of plasminogen activator release into the circulation during the first minutes of experimental myocardial ischaemia in vitro, isolated rat hearts were perfused under optimal conditions and under conditions inducing myocardial ischaemia. In ventricular tissues the content of plasminogen a activator was measured; in the perfusate the plasminogen activator and anticoagulating activities were determined. Under optimal conditions the plasminogen activator content in contracting heart was found to be essentially the same as under in vivo conditions; in the perfusates the release of plasminogen activator and of substances possessing the anticoagulating activity was insignificant.

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Effect of taurine on the properties of guanylate cyclase (GC) of the guinea-pig cardiac sarcoplasmic reticulum was studied. The enzymatic activity increased in the presence of Mn+2 at a concentration of 0.05 mM, reaching the maximal level at a concentration of 7 mM.

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The mechanism of the decrease in the heart of cAMP content under the effect of taurine was studied. It was shown on a preparation of cytoplasmic membranes isolated from the rat heart that under the effect of taurine (10(-6)--10(-3) M) the activity of phosphodiesterase and adenylate cyclase increases to the maximum by 2.4 and 1.

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Taurine produced no effect on the cyclic nucleotides level in the heart of intact rats but sharply inhibited the cAMP and cGMP level elevation in the rat heart occuring in stress. After atropine pretreatment of the animals no effect of taurine on the heart cGMP level was observed; its effect on the cAMP level was significantly inhibited against the background of partial beta-adrenoreceptors block. It is suggested that taurine is a nonspecific regulator of the myocardial cells sensitivity to the biologically active drugs.

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14C-taurine uptake and total taurine content increase during a 15-min period of swimming. Prolongation of this period leads to more active taurine metabolism (ISA formation) but the total taurine content does not change. Active accumulation against its concentration gradient and maintenance of the taurine content at the same level during the entire period of swimming suggest that the taurine uptake and its metabolism are interdependent and very important for heart activity.

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The rat heart accumulates taurine against the concentration gradient when perfused for 60 minutes with solutions containing taurine in concentrations of 0.01 to 0.5 mM.

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