Fibrosis and bone marrow: understanding causation and pathobiology.

Bone marrow fibrosis represents an important structural change in the marrow that interferes with some of its normal functions. The aetiopathogenesis of fibrosis is not well established except in its primary form. The present review consolidates current understanding of marrow fibrosis.

Role of Glycerol Oxidation Pathways in the Reductive Acid Leaching Kinetics of Manganese Nodules Using Glycerol.

Manganese nodules from ocean bed are potential resources of Cu, Ni, and Co for which land-based deposits are scarce in India. The present work describes a novel approach of using glycerol, a nontoxic biomass-derived reductant, for the reductive acid leaching of manganese nodules. Parameters such as acid concentration, time, temperature, and pulp density were optimized for leaching.

Process Flowsheet Development for Separation of Sm, Co, Cu, and Fe from Magnet Scrap.

A complete process flowsheet to recover metal values from SmCo-type magnet scrap was investigated. The magnet scrap was leached in chloride medium at pulp density of 2% (w/v) under the optimum conditions of 15% (v/v) HCl and 5% (v/v) HO at 70 °C for 3 h, which yielded 98.5% Sm and 99% Co extractions.

Efficacy of Dichlorophenolindophenol (DCIP) as Screening Test for Hb E: Revisited.

Hb E-beta thalassemia is a major public health problem in West Bengal, India and is the predominant symptom producing thalassemia in this part of the country. To search for an easy, reliable and cost effective screening method for HbE that can be used at the community level where more sophisticated methods are not readily available. And the DCIP test was performed for the purpose.

Sustainable Process for the Extraction of Potassium from Feldspar Using Eggshell Powder.

To recover potassium from feldspar, a biowaste, i.e., eggshell, was used.

Molecular interactions of MnO@RGO (manganese dioxide-reduced graphene oxide) nanocomposites with bovine serum albumin.

Graphene based materials have attracted global attention due to their excellent properties. GO-metal oxide nanocomposites have been conjugated with biomolecules for the development of novel materials and potentially used as biomarkers. Herein, a detailed study on the interaction of Bovine serum albumin (BSA) with MnO@RGO (manganese dioxide-reduced graphene oxide) nanocomposites (NC) has been carried out.

Does Profile of Hemoglobin Eβ-thalassemia Patients Change After Splenectomy? Experience of a Tertiary Thalassemia Care Centre in Eastern India.

Hemoglobin Eβ-thalassemia is by far the commonest form of thalassemia intermedia. Its phenotype ranges from mild anemia to severe transfusion-dependency necessitating splenectomy in many patients. The present study aimed to systematically analyze both clinical as well as laboratory parameters in profile of Eβ-thalassemia patients after splenectomy in terms of transfusion requirement, infections and other complications.

Effectiveness of Prenatal Screening for Hemoglobinopathies in a Developing Country.

The thalassemias are among the most common monogenic diseases worldwide, a national health burden in India. There are estimated 7500-12,000 babies born with β-thalassemia major (β-TM) every year in this country. Couples who are at-risk of having children with hemoglobin (Hb) disorders desired to have the option of avoiding the birth of an affected child by prenatal diagnosis (PND).

B cell suppression in newborn following treatment of pregnant diffuse large B-cell lymphoma patient with rituximab containing regimen.

Non-Hodgkin lymphoma associated with pregnancy is rare. Rituximab based chemotherapy is now considered the standard of care and considered safe for the treatment of diffuse large B-cell lymphoma (DLBCL) during pregnancy but little is known about its safety profile on the fetus. A 32 y primigravida was diagnosed as DLBCL at 20 wk of gestation.

Prevalance of iron deficiency in thalassemia minor: a study from tertiary hospital.

Conflicting data are available about iron metabolism in thalassemia minors. As iron deficiency prevails largely in India, a study of 150 people was conducted to assess the iron level of β thalassemia minor. The study population comprises of 59 males and 91 female who either attended outdoor services and with diagnosed thalassemia minor by hemoglobin high performance liquid chromatography or were the parents (diagnosed thalassemia minor) of β Thalassemia patients visiting daycare services for transfusion.

Veno-occlusive disease following high dose melphalan.

Hepatic veno-occlusive disease (VOD) is one of the complications following bone marrow transplantation. This complication is uncommon after HDT for autologous SCT (ASCT) in patients with multiple myeloma (MM). Here we report on a 54 years male with MM developed VOD on day 16 of transplant.

Prevalence of hemoglobinopathies in rural Bengal, India.

India is in the thalassemia belt of the world. Both α- and β-thalassemia (α- and β-thal) are found in West Bengal, a state in the eastern part of India. There was no systematic large published study to investigate the prevalence rates of different hemoglobinopathies in West Bengal.

Defluoridation behavior of nanostructured hydroxyapatite synthesized through an ultrasonic and microwave combined technique.

The absorption performance of a nano-structured hydroxyapatite produced from a combined ultrasonic and microwave technique was examined for the removal of fluoride from contaminated water. The effect of physical and chemical parameters such as initial pH, contact time, initial fluoride concentration and temperature were investigated. The results indicated that the equilibrium adsorption data followed both the Langmuir and Freundlich isotherms, with a maximum monolayer adsorption capacity of 5.