pH-sensitive phthalocyanine-loaded polymeric nanoparticles as a novel treatment strategy for breast cancer.

Novel pH-sensitive polymeric photosensitizer carriers from the phthalocyanine (Pc) group were investigated as potential photodynamic therapy drugs for the treatment of breast cancer. Their high antiproliferative activity was confirmed by photocytotoxicity studies, which indicated their high efficacy and specificity toward the SK-BR-3 cell line. Importantly, the Pcs encapsulated in the polymeric nanoparticle (NP) carrier exhibited a much better penetration into the acidic environment of tumor cells than their free form.

Imbalance of redox homeostasis and altered cellular signaling induced by the metal complexes of terpyridine.

Compounds that can induce oxidative stress in cancer cells while remaining nontoxic to healthy cells are extremely promising for potential anticancer drugs. 2,2':6',2''-terpyridine-metal complexes possess these properties. The high level of activity (IC = 0.

Correction: Dulski et al. An Organic-Inorganic Hybrid Nanocomposite as a Potential New Biological Agent. 2020, , 2551.

In the original publication [...

Low-Basicity 5-HT Receptor Ligands from the Group of Cyclic Arylguanidine Derivatives and Their Antiproliferative Activity Evaluation.

The serotonin 5-HT receptor (5-HTR), expressed almost exclusively in the brain, affects the Cdk5 signaling as well as the mTOR pathway. Due to the association of 5-HTR signaling with pathways involved in cancer progression, we decided to check the usefulness of 5-HTR ligands in the treatment of CNS tumors. For this purpose, a new group of low-base 5-HTR ligands was developed, belonging to arylsulfonamide derivatives of cyclic arylguanidines.

Design and development of multibiocomponent hybrid alginate hydrogels and lipid nanodispersion as new materials for medical and cosmetic applications.

The multibiocomponent hybrid alginate hydrogels based on brown and sea algae, containing 100 % ingredients of natural origin were prepared by ionic crosslinking reaction of a polymeric matrix with lipid nanodispersion. To the best of the Authors' knowledge such multicomponent biobased hydrogel of promising medical and cosmetical applications for the first time was obtained in the environment of flower water, received earlier as a waste by-product from various chemical processes. An innovative hybrid alginate hydrogel that is completely biodegradable and eco-friendly was obtained following waterless and upcycling trends that are in line with the principles of sustainable development.

Is journal prestige indicator equivalent of money for humans?

In this paper, we investigate the time evolution of the rank correlation coefficients of the prestige indicators of the journals (such as Scimago Journal Rank) over 21 years, for 9856 journals in various disciplines. The observed dependencies do not differ qualitatively from those observed for the time evolution of the ranking correlations in wealth rheology among the richest people recently found by Burda et al. [Entropy 23, 842 (2021)], but quantitatively the changes in rank correlations for human wealth are much stronger than in the coefficients measuring the prestige of journals.

Universality of opinions disappearing in sociophysical models of opinion dynamics: From initial multitude of opinions to ultimate consensus.

Possibility of reaching a consensus in social systems with strong initial fragmentation is one of the most interesting issues in sociophysics. It is also intriguing what the dynamics of such processes is. To address those problems, we performed computer simulations using well-established models of social opinion formation, namely, the voter, Sznajd, and Latané models.

Universality of random-site percolation thresholds for two-dimensional complex noncompact neighborhoods.

The phenomenon of percolation is one of the core topics in statistical mechanics. It allows one to study the phase transition known in real physical systems only in a purely geometrical way. In this paper, we determine thresholds p_{c} for random-site percolation in triangular and honeycomb lattices for all available neighborhoods containing sites from the sixth coordination zone.

Thermoplastic polyurethane/POSS nanohybrids: Synthesis, morphology, and biological properties.

Recent studies show good osteoinductive properties of polyurethanes modified with polyhedral oligomeric silsesquioxanes (POSS). In this work, three types of POSS; propanediolisobutyl-POSS (PHI-POSS), disilanolisobutyl-POSS (DSI-POSS), and octahydroxybutyl-POSS (OCTA-POSS) were chemically incorporated into linear polyurethane based on an aliphatic isocyanate, hexamethylene diisocyanate (HDI), to obtain new nanohybrid PU-POSS materials. The full conversion of POSS was confirmed by Fourier transform infrared spectroscopy (FTIR-ATR) spectra of the model reactions with pure HDI.

Recovering Zipf's law in intercontinental scientific cooperation.

Scientific cooperation on an international level has been well studied in the literature. However, much less is known about this cooperation on an intercontinental level. In this paper, we address this issue by creating a collection of approximately 13.

Spectroscopic and Biological Properties of the 3-Imino-1,8-naphthalimide Derivatives as Fluorophores for Cellular Imaging.

This paper presents the photophysical and biological properties of eight 3-imino-1,8-naphthalimides. The optical properties of the compounds were investigated in the solvents that differed in their polarity (dichloromethane, acetonitrile, and methanol), including three methods of sample preparation using different pre-dissolving solvents such as dimethyl sulfoxide or chloroform. In the course of the research, it was found that there are strong interactions between the tested compounds and DMSO, which was visible as a change in the maximum emission band (λ) of the neat 3-imino-1,8-naphthalimides (λ = 470-480 nm) and between the compounds and DMSO (λ = 504-514 nm).

Thermal properties of structurally balanced systems on classical random graphs.

The dynamics of social relations and the possibility of reaching the state of structural balance (Heider balance) under the influence of the temperature modeling the social noise level are discussed for interacting actors occupying nodes of classical random graphs. Depending on the graph density D, either a smooth crossover or a first-order phase transition from a balanced to an imbalanced state of the system is observed with an increase in the thermal noise level. The minimal graph density Dmin for which the first-order phase transition can be observed decreases with the system size N as Dmin∝N-0.

Styrylquinazoline derivatives as ABL inhibitors selective for different DFG orientations.

Among tyrosine kinase inhibitors, quinazoline-based compounds represent a large and well-known group of multi-target agents. Our previous studies have shown interesting kinases inhibition activity for a series of 4-aminostyrylquinazolines based on the CP-31398 scaffold. Here, we synthesised a new series of styrylquinazolines with a thioaryl moiety in the C4 position and evaluated in detail their biological activity.

Identification and Biological Evaluation of a Water-Soluble Fullerene Nanomaterial as BTK Kinase Inhibitor.

Introduction: Thanks to recent advances in synthetic methodology, water-soluble fullerene nanomaterials that interfere with biomolecules, especially DNA/RNA and selected proteins, have been found with tremendous potential for applications in nanomedicine. Herein, we describe the synthesis and evaluation of a water-soluble glycine-derived [60]fullerene hexakisadduct (HDGF) with T symmetry, which is a first-in-class BTK protein inhibitor.

Methods: We synthesized and characterized glycine derived [60]fullerene using NMR, ESI-MS, and ATR-FT-IR.

Are Natural Compounds a Promising Alternative to Synthetic Cross-Linking Agents in the Preparation of Hydrogels?

The main aim of this review is to assess the potential use of natural cross-linking agents, such as genipin, citric acid, tannic acid, epigallocatechin gallate, and vanillin in preparing chemically cross-linked hydrogels for the biomedical, pharmaceutical, and cosmetic industries. Chemical cross-linking is one of the most important methods that is commonly used to form mechanically strong hydrogels based on biopolymers, such as alginates, chitosan, hyaluronic acid, collagen, gelatin, and fibroin. Moreover, the properties of natural cross-linking agents and their advantages and disadvantages are compared relative to their commonly known synthetic cross-linking counterparts.

Vanishing Opinions in Latané Model of Opinion Formation.

In this paper, the results of computer simulations based on the Nowak-Szamrej-Latané model with multiple (from two to five) opinions available in the system are presented. We introduce the noise discrimination level (which says how small the clusters of agents could be considered negligible) as a quite useful quantity that allows qualitative characterization of the system. We show that depending on the introduced noise discrimination level, the range of actors' interactions (controlled indirectly by an exponent in the distance scaling function, the larger the exponent, the more influential the nearest neighbors are) and the information noise level (modeled as social temperature, which increases results in the increase in randomness in taking the opinion by the agents), the ultimate number of the opinions (measured as the number of clusters of actors sharing the same opinion in clusters greater than the noise discrimination level) may be smaller than the number of opinions available in the system.

Mean-field approximation for structural balance dynamics in heat bath.

A critical temperature for a complete signed graph of N agents where the time-dependent polarization of links tends towards the Heider (structural) balance is found analytically using the heat-bath approach and the mean-field approximation as T^{c}=(N-2)/a^{c}, where a^{c}≈1.71649. The result is in perfect agreement with numerical simulations starting from the paradise state where all links are positively polarized as well as with the estimation of this temperature received earlier with much more sophisticated methods.

Random site percolation on honeycomb lattices with complex neighborhoods.

We present a rough estimation-up to four significant digits, based on the scaling hypothesis and the probability of belonging to the largest cluster vs the occupation probability-of the critical occupation probabilities for the random site percolation problem on a honeycomb lattice with complex neighborhoods containing sites up to the fifth coordination zone. There are 31 such neighborhoods with a radius ranging from one to three and containing 3-24 sites. For two-dimensional regular lattices with compact extended-range neighborhoods, in the limit of the large number z of sites in the neighborhoods, the site percolation thresholds follow the dependency ∝ 1 / z, as recently shown by Xun et al.

Cellular Localization of Nonfluorescent [60]Fullerene Nanomaterial in MCF-7 Breast Cancer Cells.

Cellular localization of carbon nanomaterials in cancer cells is essential information for better understanding their interaction with biological targets and a crucial factor for further evaluating their biological properties as nanovehicles or nanotherapeutics. Recently, increasing efforts to develop promising fullerene nanotherapeutics for cancer nanotechnology have been made. However, the main challenge regarding studying their cellular effects is the lack of effective methods for their visualization and determining their cellular fate due to the limited fluorescence of buckyball scaffolds.

Does Social Distancing Matter for Infectious Disease Propagation? An SEIR Model and Gompertz Law Based Cellular Automaton.

In this paper, we present stochastic synchronous cellular automaton defined on a square lattice. The automaton rules are based on the SEIR (susceptible → exposed → infected → recovered) model with probabilistic parameters gathered from real-world data on human mortality and the characteristics of the SARS-CoV-2 disease. With computer simulations, we show the influence of the radius of the neighborhood on the number of infected and deceased agents in the artificial population.

Glioblastoma: Pitfalls and Opportunities of Immunotherapeutic Combinations.

Glioblastoma multiforme (GBM) is the most common and aggressive primary central nervous system tumour in adults. It has extremely poor prognosis since the current standard of care, comprising of gross total resection and temozolomide (TMZ) chemoradiotherapy, prolongs survival, but does not provide a durable response. To a certain extent, this is due to GBM's heterogeneous, hostile and cold tumour microenvironment (TME) and the unique ability of GBM to overcome the host's immune responses.

High pressure as a novel tool for the cationic ROP of γ-butyrolactone.

In this study, we report the acid-catalyzed and high pressure assisted ring-opening polymerization (ROP) of γ-butyrolactone (GBL). The use of a dually-catalyzed approach combining an external physical factor and internal catalyst (trifluoromethanesulfonic acid (TfOH) or -toluenesulfonic acid (PTSA)) enforced ROP of GBL, which is considered as hardly polymerizable monomer still remaining a challenge for the modern polymer chemistry. The experiments performed at various thermodynamic conditions ( = 278-323 K and = 700-1500 MPa) clearly showed that the high pressure supported polymerization process led to obtaining well-defined macromolecules of better parameters ( = 2200-9700 g mol; = 1.

Synthesis and applications of [60]fullerene nanoconjugate with 5-aminolevulinic acid and its glycoconjugate as drug delivery vehicles.

The 5-aminolevulinic acid (5-ALA) prodrug is widely used in clinical applications, primarily for skin cancer treatments and to visualize brain tumors in neurosurgery. Unfortunately, its applications are limited by unfavorable pharmacological properties, especially low lipophilicity; therefore, efficient nanovehicles are needed. For this purpose, we synthesized and characterized two novel water-soluble fullerene nanomaterials containing 5-ALA and d-glucuronic acid components.

Thermal properties of structurally balanced systems on diluted and densified triangulations.

The dynamics of social relations and the possibility of reaching the state of structural balance (Heider balance) are discussed for various networks of interacting actors under the influence of the temperature modeling the social noise level. For that purpose, two main types of lattices are considered. The first is created by removing some links from a regular triangular lattice to produce a diluted triangular lattice, and the second by adding more links to create an enhanced triangular lattice.

Anticancer potential and through study of the cytotoxicity mechanism of ionic liquids that are based on the trifluoromethanesulfonate and bis(trifluoromethylsulfonyl)imide anions.

Ionic liquids (ILs) are known for their unique physicochemical properties. However, despite the great number of published papers, still little attention has been paid to their biological activity. Anticancer potential and the molecular mechanisms underlying the toxicity of these compounds are especially interesting and still unexplored.