Prediction of incident hypertension and arterial stiffness using the non-insulin-based metabolic score for insulin resistance (METS-IR) index.

Hypertension is associated with insulin resistance (IR), metabolic syndrome (MS), and arterial stiffness. Non-insulin-based IR indexes were developed as tools for metabolic screening. Here, we aimed to evaluate the novel non-insulin-based Metabolic Score for IR (METS-IR) index for the prediction of incident hypertension and arterial stiffness evaluated using pulse wave velocity (PWV) analysis, compared with other non-insulin-based IR indexes.

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.

Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals with type 2 diabetes (T2D) and 24,440 non-diabetic control participants from 5 ancestries. We identify gene-level associations of rare variants (with minor allele frequencies of less than 0.

Development and validation of a predictive model for incident type 2 diabetes in middle-aged Mexican adults: the metabolic syndrome cohort.

Background: Type 2 diabetes mellitus (T2D) is a leading cause of morbidity and mortality in Mexico. Here, we aimed to report incidence rates (IR) of type 2 diabetes in middle-aged apparently-healthy Mexican adults, identify risk factors associated to ID and develop a predictive model for ID in a high-risk population.

Methods: Prospective 3-year observational cohort, comprised of apparently-healthy adults from urban settings of central Mexico in whom demographic, anthropometric and biochemical data was collected.

Taste perception in normal and overweight Mexican adults.

The prevalence of obesity in Mexico is the highest in the world, with almost 70% of adults being classified as overweight or obese. The increased prevalence of obesity in Mexico, and globally, may be related to the changing food environment, providing increased access to highly palatable, but obesogenic, food products. One potential mechanism for this association is changing food perceptions, an area poorly studied in transitional countries.

Telomere length and type 2 diabetes in males, a premature aging syndrome.

Background: Increased telomere shortening has been demonstrated in several diseases including type 2 diabetes. However, it is not known whether telomere length changes during the course of type 2 diabetes.

Objective: To determine telomere length at different stages of type 2 diabetes, including early and late stages.

Association between telomere length and C-reactive protein and the development of coronary collateral circulation in patients with coronary artery disease.

Background: Coronary collateral circulation is a stabilizer factor in myocardial ischemia. We attempted to establish a link between collateral circulation, C-reactive protein (CRP), and telomere shortening.

Patients And Methods: A case-control study was performed in patients with (group A) and without (group B) coronary collaterals using coronariography.

[Cardiovascular magnetic resonance evaluation of left-to-right shunts due to cardiac septal defects in patients with pulmonary arterial hypertension].

Introduction And Objectives: As cardiac septal defects are frequently associated with pulmonary arterial hypertension, hemodynamic assessment is essential before deciding on surgery. The aim of this study was to evaluate the use of cardiovascular magnetic resonance imaging for assessing cardiac shunts and for quantifying pulmonary artery systolic pressure in patients with cardiac septal defects.

Methods: This cross-sectional study involved patients with cardiac septal defects and clinically suspected severe pulmonary arterial hypertension who had an indication for cardiac catheterization and in whom magnetic resonance imaging was not contraindicated.

[Symptomatic profile in peri and postmenopausal women].

Objective: To determine the symptoms that women refer during peri and postmenopause.

Patients And Method: A cross-sectional study was carried out from April to December 2005; 500 women between 45 and 65 years old were included. We applied them the NR 1 questionnaire of symptoms for mature women.

Auditory impairment in patients with type 2 diabetes mellitus.

Background: We assessed the auditory function of 94 patients with type 2 diabetes mellitus and 94 age- and sex-matched healthy subjects.

Methods: To study the influence of the clinical characteristics of the disease on the auditory function, after a clinical interview with ophthalmological assessment, subjects were evaluated using pure-tone audiometry, speech audiometry, auditory brainstem responses, the Michigan Diabetic Neuropathy Score and albuminuria. The mean age when diabetes was diagnosed was 42.

The opioid system and excitatory amino acids in the onset of puberty in female rats.

The control of sexual maturation by the hypothalamus is incompletely understood. The activation and/or removal of inhibition of gonadotropin-releasing hormone (GnRH) secretion at puberty involves several neurotransmitters. Excitatory amino acids (EAA), such as L-glutamic acid (L-GLU), may increase gonadotropin secretion acting on N-methyl-D-aspartate (NMDA) and non-NMDA receptors.

[Correlations between hyperprolactinemia and galactorrhea].

In a prospective study performed between January, 1989 to August, 1988, we evaluated the association between hyperprolactinemia and its clinical features. Of the 58 subjects included: 23 had hyperprolactinemia and 35 were controls. The most frequent clinical manifestations in hyperprolactinemic patients were galactorrhea (43.

[Elective appendectomy associated with cesarean section].

A prospective study was conducted in 90 patients divided in two different groups: the first group included 45 labor patients operated of cesarean section and elective appendectomy, the second group included 45 labor patients operated of cesarean section without appendectomy (control group). The purpose was to evaluate if the elective removal of the appendix increase the postoperative morbidity. The most common indication of cesarean section was the mother-fetus disproportion (55.