Publications by authors named "Mala T"

Objective: Little is known about the longer-term maintenance, remission, or development of binge eating behaviour (BE) following metabolic and bariatric surgery (MBS). This brief report investigated BE prior to and 10 years following MBS and examined mental health and weight outcomes between BE groups (never BE, continued BE, remitted BE, or developed 'de novo' BE).

Method: One hundred and eighty-three participants (76.

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  • Previous studies hinted at a link between body fat and penile cancer risk, but evidence was limited; this study analyzed 829,081 Norwegian men to explore the relationship between BMI and penile cancer incidence.
  • Over 25 million person-years of follow-up revealed that higher BMI was associated with increased risk of penile cancer, with significant hazard ratios for those with BMI over 30.
  • The findings suggest that obesity correlates with higher penile cancer risk, indicating a need for more research to understand the underlying causes.
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  • This study evaluates the effectiveness of Robot-assisted minimally invasive esophagectomy (RAMIE) for treating esophageal cancer at various centers globally, aiming to pinpoint areas for enhancement in surgical outcomes.
  • Over three time periods (2016-2023), data from 28 centers was analyzed, revealing improvements in textbook outcome rates, lymph node yields, and decreased hospital stays, particularly with McKeown procedures.
  • The results showed varying success rates in surgical outcomes and complications, with a noteworthy decrease in anastomotic leakage rates and hospital stays over time, highlighting advancements in surgical techniques.
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  • A study examined the link between body mass index (BMI) and the risk of vulvar and vaginal cancer in a large group of Norwegian women, involving 889,441 participants aged 16-75.
  • The results indicated that higher BMI is associated with an increased risk of both types of cancer, with significant hazard ratios (HRs) showing a strong connection for higher BMI groups.
  • Notably, the risk appears to be greater when considering BMI during early adulthood, particularly for early-onset vaginal cancer, suggesting the need for further research to understand this relationship better.
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Effective drug delivery is the cornerstone of modern healthcare, ensuring therapeutic compounds reach their intended targets efficiently. This paper explores the potential of personalized and holistic healthcare, driven by the synergy between traditional and allopathic medicine systems, with a specific focus on the vast reservoir of medicinal compounds found in plants rooted in the historical legacy of traditional medicine. Motivated by the desire to unlock the therapeutic potential of medicinal plants and bridge the gap between traditional and allopathic medicine, this survey delves into in-silico computational approaches for studying Drug-Target Interactions (DTI) within the contexts of allopathy and siddha medicine.

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Background: Common bile duct stones occur in 2-12 % of all patients who undergo laparoscopic cholecystectomy. Laparoscopic transcystic extraction of bile duct stones as a one-step procedure is an alternative to endoscopic retrograde cholangiopancreatography (ERCP), with comparable success and complication rates. The study aimed to survey the clinical course in patients who underwent transcystic stone extraction and cholecystectomy simultaneously.

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Importance: Results from long-term follow-up after biliopancreatic diversion with duodenal switch (DS) are scarce.

Objective: To compare weight loss, health outcomes, and quality of life 10 years or more after Roux-en-Y-gastric bypass (RYGB) and DS surgery in patients with severe obesity-that is, a body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) of 50 to 60.

Design, Setting, And Participants: This open-label randomized clinical trial was conducted at 2 academic bariatric centers in Sweden and Norway.

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Anastomotic leakage (AL) is a dreaded complication following esophageal resection. No clear consensus exist for the optimal handling of this severe complication. The aim of this study was to describe the treatment outcome following AL.

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Esophagectomy is a complex and complication laden procedure. Despite centralization, variations in perioparative strategies reflect a paucity of evidence regarding optimal routines. The use of nasogastric (NG) tubes post esophagectomy is typically associated with significant discomfort for the patients.

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Introduction: A large variation in outcome has been reported after sleeve gastrectomy (SG) across countries and institutions. We aimed to evaluate the effect of surgical technique on total weight loss (TWL) and gastro-esophageal reflux disease (GERD).

Methods: Observational cohort study based on data from the national registries for bariatric surgery in the Netherlands, Norway, and Sweden.

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Background/aim: This study sought to explore the life situation of male patients at a critical stage after surgery for esophageal cancer and to enlighten their need for support from healthcare providers during their return to daily life.

Patients And Methods: In-depth and semi-structured interviews were conducted with six patients following surgery for esophageal cancer. The interview data were analyzed via inductive thematic analysis.

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Background: Calculous gall bladder disease is often handled by laparoscopic cholecystectomy. In cases where a safe dissection of the hepatocystic triangle cannot be carried out, a subtotal cholecystectomy (STC) may be performed. The perioperative management of patients undergoing STC is characterized by limited evidence.

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Background: Mini-gastric bypass is a new surgical method for the treatment of morbid obesity. The method was introduced at Oslo University Hospital in 2016.

Material And Method: We performed a retrospective analysis of prospective data collected over a two-year period following mini-gastric bypass between 1 March 2016 and 1 April 2021.

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Objective: To gain insight into the global practice of robot-assisted minimally invasive gastrectomy (RAMIG) and evaluate perioperative outcomes using an international registry.

Background: The techniques and perioperative outcomes of RAMIG for gastric cancer vary substantially in the literature.

Methods: Prospectively registered RAMIG cases for gastric cancer (≥10 per center) were extracted from 25 centers in Europe, Asia, and South-America.

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Background: The aim of this study was to explore the associations between BMI and cancer of the liver, bile ducts, and gallbladder.

Methods: A registry-based cohort study was performed by linking data from several national registries in Norway.

Results: The cohort comprised 1 723 692 individuals including 4768 hepatobiliary cancer cases during 55 743 509 person-years of follow-up.

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Objectives: The aims of this study were to investigate modifications in pain sensitivity after RYGB and to explore associations between pain sensitivity and weight loss, chronic abdominal pain, total body pain, anxiety, depression, and pain catastrophizing.

Methods: In total, 163 patients with obesity were examined with a cold pressor test for pain sensitivity before and two years after RYGB. Two aspects of pain sensitivity were registered: Pain intensity (numeric rating scale, range 0-10) and pain tolerance (seconds).

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Background And Aim: Cognitive Computing systems are the intelligent systems that thinks, understands and augments the capabilities of human brain by blending the technologies of Artificial Intelligence, Machine Learning and Natural Language Processing. In recent days, maintenance or enhancement of health by preclusion, prognosis, and analysis of diseases has become a challenging task. The increasing diseases and its causes becomes a big question before humanity.

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