Publications by authors named "Mal Eutick"
Arsenic trioxide (ATO) has been shown to inhibit pancreatic cancer (PC) cell growth and to promote the inhibitory effects of gemcitabine (Gem) on PC . However, the high toxicity of ATO associated with the required high doses and indiscriminate targeting has limited its clinical application. This study aimed to determine whether coupling arsenic to a tumor homing peptide would increase the inhibitory potency against PC cells.
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- The study examined how blocking Fe binding in gastrin with Bi, In, or Ru ions affected tumor growth in APC mice, revealing Bi reduced larger tumor counts while In and Ru worsened tumor burden.
- The stronger binding efficiency of In and Ru compared to Bi suggests that Bi's tumor-reducing effect isn't due to decreased gastrin activity, prompting further research into higher Bi doses for longer treatment periods.
The peptide hormone gastrin (Gamide) binds trivalent metal ions, including indium (In), ruthenium (Ru) and gallium (Ga), with high affinity. Complexes of gastrin with chelated isotopes of In and Ga have previously been used for the location of tumours expressing the cholecystokinin 2 receptor (CCK2R). The aim of the present study was to purify the complexes of Gamide with radioactive isotopes of In, Ru or Ga and to investigate their ability to bind to the CCK2R.
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