Publications by authors named "Makyo Ueda"

Article Synopsis
  • Soluble CLEC-2 (sCLEC-2) is proposed as a potential biomarker for monitoring platelet activation using routine blood samples, with a newly developed rapid chemiluminescence enzyme immunoassay (CLEIA) that gives results in about 19 minutes.
  • The study evaluated the performance of the CLEIA method in terms of sensitivity, precision, and correlation with the established ELISA method, finding that it performed well and had similar reference ranges for healthy individuals.
  • Additionally, the research explored the different molecular forms of sCLEC-2 in patient samples, revealing that the CLEIA method primarily detects the shed form of sCLEC-2, suggesting its potential clinical relevance.
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Predicting the clinical course and allocating limited medical resources appropriately is crucial during the COVID-19 pandemic. Platelets are involved in microthrombosis, a critical pathogenesis of COVID-19; however, the role of soluble CLEC-2 (sCLEC-2), a novel platelet activation marker, in predicting the prognosis of COVID-19 remains unexplored. We enrolled 108 patients with COVID-19, hospitalized between January 2021 and May 2022, to evaluate the clinical use of sCLEC-2 as a predictive marker.

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