DYNAMICS OF CHANGES IN THE MICROBIAL PICTURE OF THE ORAL CAVITY ON THE BACKGROUND OF CHRONIC OPIOID EXPOSURE IN THE EXPERIMENT.

Objective: The aim is to investigate changes in the microbiota of dental biofilm at the end of the eighth, tenth and twelfth weeks of experimental opioid exposure.

Patients And Methods: Materials and methods: The study was performed on 36 white outbred adult male rats, which were injected with the opioid analgesic nalbuphine in increasing doses (0,212 - 0,3 mg / kg) during 8, 10 and 12 weeks. Qualitative and quantitative composition of microbiota of dental biofilm was studied using statistical analysis.