[Lymphotropic therapy in patients after surgical revascularization of lower-limb vessels].

Occlusive and stenotic lesions of lower-limb arteries appear to be amongst the most common manifestations of the pathology of the cardiovascular system and are characterized by various degree of chronic arterial insufficiency. Revascularization is the main stage of treatment for chronic arterial insufficiency of the lower extremities. Performing a reconstructive operation aimed at restoring the arterial blood flow in the ischaemized extremity is accompanied and followed by the development of reperfusion syndrome.

[Total revascularization of the lower limb in a patient with multifocal atherosclerosis and critical ischaemia].

Described in the article is a clinical case report regarding revascularization of the entire arterial bed of the lower extremity in a male patient presenting with multifocal atherosclerosis, stenoses of the arteries of the iliofemoral segment, occlusions of the superficial femoral artery, popliteal artery and arteries of the crus. Clinically, the patient was diagnosed as having critical ischaemia of the lower limb with wet necrosis of the toes. The patient simultaneously underwent semiclosed loop endarterectomy from the arteries of the femoropopliteal segment with the help of the Vollmar rings, autovenous popliteal-tibial prosthetic repair, as well as exarticulation of the toes.

P2Y2 receptor agonist with enhanced stability protects the heart from ischemic damage in vitro and in vivo.

Extracellular nucleotides acting via P2 receptors play important roles in cardiovascular physiology/pathophysiology. Pyrimidine nucleotides activate four G protein-coupled P2Y receptors (P2YRs): P2Y2 and P2Y4 (UTP-activated), P2Y6, and P2Y14. Previously, we showed that uridine 5'-triphosphate (UTP) activating P2Y2R reduced infarct size and improved mouse heart function after myocardial infarct (MI).