[The application of artificial intellect in health care: prospects and challenges for science and clinical medicine].

The paper analyses publications data related to issues of application of AI and machine learning systems in medical science and practice. The particular attention is paid to key points of AI application in health care: diagnostics, telemedicine, development of new medications, medical rehabilitation and management decision-making process. Despite broad perspectives of applying the given systems in clinical practice and pharmaceutical industry, there are a number of such unsolved problems as ensuring information security, risk of making erroneous decisions and necessity to change existing normative legal base of health care.

[The pharmacogenetics as integral part of personalized medicine: problems and prospects].

The article considers issues of implementation into clinical practice the principles of 5P medicine in its part of individualization of therapeutic tactics considering genetic characteristics of patients. The analysis of studies concerning influence of allelic variations on metabolism, safety and tolerance of the most often prescribed medicinal preparations was implemented. The main assumptions of pharmacogenomics were considered.

A Simple Way for the Preparation of Natural Antioxidant Quercetin from Rutin by Subcritical Water.

Context: Quercetin (QR) is a natural strong antioxidant of the plant origins. It is used for treating conditions of heart and blood vessels including "hardening of arteries" (atherosclerosis), high cholesterol, heart disease, circulation problems, preventing cancer, for treating chronic infections of the prostate, etc.

Aims: The aim of this work was to development and study of an acid-free technique for the preparation of QR from rutin (RT) that requires no use of acids and toxic organic solvents.

[STUDY OF COMPOSITION OF PLANT EXTRACTS, POSSESSING ANTIMICROBIAL EFFECT AGAINST VIBRIO CHOLERAE EL TOR, USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY].

Aim: Study the composition of plant extracts using high-performance liquid chromatography. (HPLC) and evaluation of their antimicrobial effect against Vibrio cholerae El Tor.

Materials And Methods: Qualitative and quantitative composition of plant extracts was studied using HPLC.

Study of an Acid-Free Technique for the Preparation of Glycyrrhetinic Acid from Ammonium Glycyrrhizinate in Subcritical Water.

The aim of this work was to study an application of a previously developed expedient acid-free technique for the preparation of glycyrrhetinic acid from ammonium glycyrrhizinate that requires no use of acids and toxic organic solvents. Subcritical water that serves as a reactant and a solvent was used in order to obtain glycyrrhetinic acid in good yields starting from ammonium glycyrrhizinate. It has been shown that variation of only one parameter of the process (temperature) allows alteration to thecomposition of the hydrolysis products.

Study of molecular complexation of glycyrrhizic acid with chloramphenicol by electrospray ionization mass spectrometry.

Context: Glycyrrhizic acid (GA) is a triterpene glycoside representing the main active component of licorice root extract obtained from plants of the Glycyrrhiza glabra L. and widely used as a complex-forming agent for the synthesis of new transport forms of the well-known drugs.

Aims: For the first time, the complexation of GA with chloramphenicol antibiotic (ChlA) was investigated by electrospray ionization mass spectrometry (ESI MS).

[The characteristics of morphofunctional status of rural schoolchildren].

The authors made a complex evaluation of the physical development of 7-16-year-old rural schoolchildren from a large administrative territorial entity and developed age-gender-related standards, by using the percentile technique. There were significant morphofunctional differences between the urban and rural schoolchildren at the present stage of a secular trend, which determines the necessity of developing the physical development standards for rural children and adolescents in order to correctly interpret the data on their health status.

[Comparison of the tocolytic and hemodynamic effects of calcium channel blockers in pregnant rats].

It was demonstrated in experiments on pregnant rats that toxolytic doses of the calcium channel blockers nifedipine, cardiazem (diltiazem) and verapamyl reduce blood pressure, heart rate, and doppler ultrasound velocity in the uterine artery. Toxolytic doses of sensit (fendilin) do not change hemodynamics in pregnant rats.

[Neurotrophic regulation of the restorative processes in muscle autografts in vertebrates].

In frogs, tortoises and rats autotransplantation of the whole gastrocnemius muscle has been performed into its own bed at sewing the nerve to the autotransplant and at its denervation. Fragments of the skeletal muscles are also transplanted into the brain and into the spinal cord in frogs and rats. By means of light and electron microscopy, restorative processes are studied in the transplanted muscles.