Publications by authors named "Makris M"

Remission of asthma can occur as part of the natural history of the disease; however, the use of biologics can result in disease remission in some patients. In this post hoc analysis of the RELIght study, we aimed to evaluate clinical remission in real life among patients treated with mepolizumab, to detect possible differences between "remitters" and "nonremitters," and to evaluate possible predictors of remission. Clinical remission was defined as the absence of asthma exacerbations, discontinuation of oral corticosteroids (OCS), achievement of asthma control (Asthma Control Test [ACT] ≥ 20), and stable or improved lung function.

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This Anaphylaxis Manifesto calls on communities to prioritise 10 practical actions to improve the lives of people at risk of serious allergic reactions. The Global Allergy and Asthma European Network and the European Federation of Allergy and Airways Diseases Patients' Associations (EFA) compiled patient-centric priorities. We used qualitative consensus methods, research evidence and feedback from over 200 patient groups, stakeholder organisations and healthcare professionals.

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  • * A study in Greece involved 184 adults, revealing that many suffer from additional issues like obesity and allergic comorbidities, with the majority receiving specific treatment for their condition.
  • * Key findings included high rates of pain, severe itching, and sleep disturbances, with patients reporting substantial reductions in work productivity and overall well-being.
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  • - Patient-reported outcome measures (PROMs) are tools that help assess a patient's health at a specific time and are important for personalized healthcare.
  • - The paper reviews the use of visual analog scales (VAS) for measuring asthma and allergic rhinitis control, particularly focusing on the MASK-air app, which includes electronic VAS forms.
  • - A randomized controlled trial was conducted to validate the electronic VAS, and further evaluations confirmed the effectiveness of VAS questions and additional medication scores for allergic asthma symptoms.
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People with bleeding disorders (PWBD) have been exposed to the risk of developing chronic viral hepatitis and cirrhosis after replacement therapy. Today, the advent of new pharmacologic strategies for the control of hemostasis and the efficacious antiviral therapies against hepatitis C virus and hepatitis B virus have significantly reduced this risk. However, the definitive success for liver health in this clinical setting is also influenced by other factors, such as the severity of liver disease at the time of hepatitis B virus/hepatitis C virus antiviral therapy and the exposure to highly prevalent factors of chronic liver damage (eg, metabolic dysfunction and/or alcohol) that can cause a residual risk of complications such as hepatocellular carcinoma, portal hypertension, and liver insufficiency.

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  • The study looked at how safe allergen immunotherapy (AIT) is in real-life situations by keeping track of any negative reactions people had.
  • They found that out of 1,545 adults getting AIT for allergies, only a small number (about 7.4%) experienced adverse events, and serious reactions were very rare.
  • Having asthma and using a certain type of AIT called subcutaneous immunotherapy (SCIT) put some people at a higher risk of side effects, while using modified allergens seemed to help reduce the risk.
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  • * The International Society on Thrombosis and Haemostasis developed a comprehensive clinical practice guideline to assist patients, caregivers, and healthcare professionals in making informed treatment decisions for congenital hemophilia A and B.
  • * A diverse panel of experts prioritized 13 key clinical questions regarding treatment strategies, utilizing the GRADE approach for systematic evidence review, and sought public feedback on their recommendations.
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Background: Patients with hemophilia have a life-long risk of developing neutralizing antibodies (inhibitors) against clotting factor concentrates. After the first 50 exposure days (EDs), ie, in previously treated patients (PTPs), data on inhibitor development are limited.

Objectives: To report inhibitor development according to factor (F)VIII or FIX concentrate use in PTPs with severe hemophilia A and B.

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  • - Hodgkin lymphoma (HL) is a rare type of cancer that features specific cells called Hodgkin or Reed-Sternberg cells.
  • - Cardiac issues related to HL are not well-studied, with limited reports on conditions like cardiac tamponade in these patients.
  • - A case is presented of a 21-year-old woman whose initial HL symptoms included cardiac tamponade, underscoring the need for quick diagnosis and treatment of related heart complications.
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  • - The traditional healthcare approach often overlooks patients' personal experiences and strengths, focusing mainly on disease treatment. Person-centered care aims to align medical decisions with individual values and preferences, particularly for those with chronic conditions.
  • - This paper seeks to enhance care for rhinitis and asthma by developing digital care pathways and incorporating real-world evidence to create a more patient-centered approach.
  • - Key components of the review include advancements in mHealth, the integration of artificial intelligence, a novel classification system for airway diseases, and proposals for the ARIA 2024 guidelines, all targeting a sustainable and applicable healthcare model.
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Factor VIII and IX clotting factor concentrates manufactured from pooled plasma have been identified as potent sources of virus infection in persons with hemophilia (PWHs) in the 1970s and 1980s. To investigate the range and diversity of viruses over this period, we analysed 24 clotting factor concentrates for several blood-borne viruses. Nucleic acid was extracted from 14 commercially produced clotting factors and 10 from nonremunerated donors, preserved in lyophilized form (expiry dates: 1974-1992).

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  • - The study investigates how the number of allergens a person is sensitized to (monosensitized vs polysensitized) affects the severity and variety of symptoms in patients with allergic rhinitis (AR).
  • - Results show that polysensitized patients reported more symptoms, especially itchy eyes and wheezing, compared to monosensitized patients, indicating that having multiple sensitivities leads to a greater symptom burden.
  • - The research concludes that greater sensitization correlates with a wider range of symptoms and suggests that different levels of sensitization may affect various organs in the body.
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  • A significant percentage (31.2%) of patients with chronic spontaneous urticaria (CSU) experience non-skin-related symptoms (NSRS) like recurrent fever, joint/bone/muscle pain, and malaise.
  • These NSRS are linked to various trigger factors such as food and infections, as well as clinical characteristics like sleep disturbances and elevated inflammation markers.
  • Patients with NSRS tend to have worse disease activity, longer duration of CSU, lower quality of life, and a higher likelihood of poor control over their symptoms, highlighting the need for improved management strategies.
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Registries are excellent sources of data to address questions that are typically not evaluated in randomized clinical trials, including natural history, disease prevalence, treatment approaches and adverse events, and models of care. Global and regional registries can provide data to identify differences in outcomes and in haemophilia care between countries, economic settings, and regions, while facilitating research and data sharing. In this manuscript, we highlight five bleeding disorder registries: Country registries from Australia and China, Paediatric Network on Haemophilia Management (PedNet) data on children who have received emicizumab, data from the European Haemophilia Safety Surveillance (EUHASS) system, and data on women and girls with haemophilia from the World Federation of Haemophilia (WFH) registries.

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Angiotensin-converting enzyme (ACE) inhibitors are used primarily in the treatment of hypertension, heart failure, and in the acute phase of myocardial infarction. Lisinopril [N-[(1S)-1-car-boxy-3-phenylpropyl]-L-lysyl-L-proline], enalapril [(S)-1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline] and ramipril [2-aza-bicyclo-[3.3.

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  • A documented case highlights a patient who initially tolerated etoricoxib after a FDE from nimesulide but later developed an etoricoxib-induced FDE with severe symptoms.
  • This suggests the need for more awareness in medicine regarding drug sensitivities and highlights the importance of further research to understand FDE mechanisms and improve diagnostics.
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As treatments for individuals with inherited bleeding disorders improve, life expectancy increases and is approaching that of the normal population. Concomitant with this we are now seeing the problems of ageing in the bleeding disorder population. Although the clear-cut association between low clotting factor levels and risk of bleeding is well recognised, a relationship between high levels, some non-factor therapies and thrombotic risk also exists.

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Atopic dermatitis (AD) is a recurrent, chronic, inflammatory, itchy skin disorder that affects up to 20% of the pediatric population and 10% of the adult population worldwide. Onset typically occurs early in life, and although cardinal disease features are similar across all ages, different age groups and ethnicities present distinct clinical characteristics. The disease imposes a significant burden in all health-related quality of life domains, both in children and adults, and a substantial economic cost both at individual and national levels.

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