The Outcomes of Ponatinib Therapy in Patients With Chronic Myeloid Leukemia Resistant or Intolerant to Previous Tyrosine Kinase Inhibitors, Treated in Poland Within the Donation Program.

Introduction: Tyrosine kinase inhibitors (TKIs) have greatly improved the treatment outcome for most patients with chronic myeloid leukemia (CML). Ponatinib is a new pan-inhibitor of TK active in resistant CML. This study aimed to evaluate the efficacy and safety of ponatinib in patients suffering from CML.

[The role of human papillomaviruses (HPV) in upper respiratory tract diseases].

High-risk papillomaviruses (HPVs) are etiologic agents for anogenital tract cancers and have been detected in head and neck squamous cell carcinomas. Still a viral etiology of head and neck cancers had not been established unambiguously. For head and neck cancers two major risk factors (tobacco smoke and alcohol) have been recognised and HPV infection may play a synergistic role in the multifactorial etiology of the tumors.

[Human papillomavirus (HPV) in laryngeal leukoplakia].

Epidemiological data and results of molecular studies suggest that human papillomavirus could be considered a risk factor for the upper respiratory tract cancers. HPV infection plays also the important role in the laryngeal precancerous states. Six out of 16 studied cases of laryngeal leukoplakia revealed presence of HPV DNA (37.

[Human papillomavirus (HPV) in the laryngeal carcinoma].

Epidemiological data and results of molecular studies suggest that human papillomavirus has been considered a risk factor in upper respiratory tract cancers. 10 out of 23 studied cases of laryngeal carcinoma revealed presence of HPV DNA (43.5%).

[Cytologic nasal smears in patients with mucoviscidosis].

58 cytological smears taken from the surface of the nasal mucosa of patients with mucoviscidosis were analysed. In 69% of the smears prevalence of pseudostratified columnar epithelium was present. Squamous metaplastic changes was found in 31% of the smears.

[Bacteriological examination of the content from neck cysts].

Bacteriological examination of the material obtained from neck cysts by fine needle aspiration biopsy was performed. In 96.2% of cases no microbiological infection was found.

[The role of human papillomavirus (HPV) infection in the pathogenesis of the laryngeal cancer].

In the paper the role of virus infection in carcinogenesis was presented. Particular significance of human papillomavirus infection in the neoplastic diseases, also in the laryngeal cancer was emphasized.

[Difficulties in the aspiration cytodiagnosis of the neck tumors].

Since 1971 FNA is used at the ENT Department Medical Academy in Warsaw in the diagnosis of the neck and head tumors. This method was effective in 87.4% of cases.

[The significance of the cytological evaluation in the early diagnosis of the laryngeal carcinoma].

The aim of the study was to find out how useful is the cytological examination in the detection of the laryngeal carcinoma. 70 cytological smears from the larynx were taken in the group of 35 patients with carcinoma of the larynx treated at the ENT Clinic. In 91% for the cases the agreement between cytological and histopatological results was found.

[Evaluation of complications after fine-needle biopsy of polymorphic adenoma from materials of the Otolaryngologic Clinic AM in Warsaw in the years 1983-1988].

The authors, who have an ample experience with thin-needle biopsy in the routine diagnosis of head and neck tumors present the results of analysis of 56 patients with salivary glands and adenomatous tissue of the platelet adenoma. The analysis showed, that early complications after this procedure are very rare. Properly performed thin-needle biopsy assured the oncological safety to the patient.

[Human papilloma virus infection in the case of larynx carcinoma].

The case of 59 year old man treated for larynx carcinoma was presented. The potentially oncogenic human papillomavirus type 16/18 was detected in the tissue surrounding the tumor.

[The application of the alloplastic prosthesis in the nasal septal perforations].

The alloplastic prosthesis in 14 patients with the nasal septal perforation is used with a good clinical results. In the cytological investigation a changes of the nasal epithelium before and after using the prosthesis were found.

[Fine needle aspiration biopsy in the diagnosis of head and neck tumors].

The results of 3039 fine needle aspiration biopsies of the head and neck tumors were presented. The comparison of cytological and histological examinations in 1141 patients showed that correct cytological diagnosis was established in 84.2% of cases.

[Use of Solcoseryl DAP after nasal septum surgery].

Solcoseryl is a biological agent, which accelerates the healing tissue procedure. This influence was studied during the nasal septum surgery. In 25 patients the postoperational nasal plug was inserted with the Solcoseryl and in 10 (control) with the paraffin.

[Cytological evaluation of nasal mucosal variability in surgically treated patients with ozena].

The cytologic examination of nasal mucosa before and after the operation of ozaena were described. Significant changing of cytological images was found. In preoperative examinations the squamous metaplasia was seen, the postoperative examinations the squamous metaplasia was seen, the postoperative findings were various.

[Cytological diagnosis of lymphomatous papillary cystadenoma].

The cytologic material of 27 papillary cystadenoma was described. The thin needle aspiration procedure was performed. In 77.

[Nasal cytology in patients with non-seasonal atopic rhinitis].

The results of the cytological evaluation of the nasal smears taken from the patients with non-seasonal atopic rhinitis were presented. In 95% of smears a very abundant cytological material of the columnar epithelium cells was found. The smears taken by cyto-brushing (Medscand) showed the presence of the cytological material from the whole nasal mucosa, while those taken by the loop contained the cells from the small area of the mucosa.

[Cytological picture of the damage and regeneration of the nasal epithelium].

The cytological pictures of the degeneration and regeneration of the columnar and squamous nasal epithelium were presented. Squamous metaplastic changes of the nasal epithelium were also discussed.

[Cytological examination of nasal discharge before and after local administration of flunisolide (syntaris)].

The influence of syntaris therapy on nasal mucosa was testified by means of the cytologic examinations. After therapy the number of the cylindric multilayer epithelial and inflammatory cells was lowered. No cell damage was observed.

[Foreign structures in cytological appearance of otolaryngological specimens].

The alien structure, being not the own cells of patient observed in cytologic specimens in otolaryngologic practice were described. The pollen, Actinomyces and mycotic cells as well as the inorganic particles were found.

[Cytologic evaluation of the nasal mucosa in workers at the Compact Automobile Factory in Tychy].

Cytological tests of nasal smears in seventy workers of a car industry plant in Tychy were carried out. Degenerative lesions of nasal epithelial cells were found.