Impact of Daikenchuto (TU-100) on the early postoperative period in duodenal-jejunal bypass.

Introduction: We investigated the effect of Daikenchuto (TU-100) on the early postoperative period in duodenal-jejunal bypass (DJB).

Methods: Study 1:The effect of TU-100 on diabetic rats was investigated. Rats were sacrificed after receiving TU-100 for one week.

Deconstructing the traditional Japanese medicine "Kampo": compounds, metabolites and pharmacological profile of maoto, a remedy for flu-like symptoms.

Pharmacological activities of the traditional Japanese herbal medicine (Kampo) are putatively mediated by complex interactions between multiple herbal compounds and host factors, which are difficult to characterize via the reductive approach of purifying major bioactive compounds and elucidating their mechanisms by conventional pharmacology. Here, we performed comprehensive compound, pharmacological and metabolomic analyses of maoto, a pharmaceutical-grade Kampo prescribed for flu-like symptoms, in normal and polyI:C-injected rats, the latter suffering from acute inflammation via Toll-like receptor 3 activation. In total, 352 chemical composition-determined compounds (CCDs) were detected in maoto extract by mass spectrometric analysis.

[Development of a statistical metabolic syndrome simulator].

Objective: The metabolic syndrome (Mets) is a clustering of cardiovascular disease risk factors: visceral obesity, hyperglycemia, hypertension and dyslipidemia. However, the criteria and definitions of Mets vary among countries, and medical evaluation is not unified as yet. The aim of the present study was to develop a Mets simulator as a tool for health policies, calculating prevalence corresponding to several diagnostic criteria based on checkup results for a group.