Successful oral desensitization with crizotinib after crizotinib-induced hepatitis in an anaplastic lymphoma kinase-rearranged non-small-cell lung cancer patient: A case report.

Crizotinib is one of the molecularly-targeted agents targeted against anaplastic lymphoma kinase (ALK)-rearranged non-small-cell lung cancer (NSCLC). Although its effects appear to be promising, crizotinib may cause adverse effects in patients with ALK-rearranged NSCLC. Hepatic laboratory abnormalities are frequently observed with crizotinib and treatment discontinuation is occasionally required.

Impairment factors for evaluating the patency of drug-eluting stents and bare metal stents in coronary arteries by 64-slice computed tomography versus conventional coronary angiography.

Purpose: To identify, using logistic regression models, factors impairing evaluation of patency of drug-eluting stents (DES) and bare metal stents (BMS) in coronary arteries by 64-slice MSCT versus conventional coronary angiography (CAG).

Materials And Methods: We evaluated 75 stents (16 DES and 59 BMS; 57 in males) implanted in 49 consecutive subjects (35 males; aged 68+/-10 years) by enhanced ECG-gated MSCT (Light Speed VCT, General Electrics) and CAG. Stents were classified by implantation site: (1) right coronary artery, (2) left anterior descending branch (LAD), and (3) left circumflex branch.

Utility of multislice computed tomography with a 64-data acquisition system for four-dimensional volumetric analysis using a pulsating phantom and considering pulsation rate and reconstruction methods.

Purpose: To evaluate 64-data acquisition system (DAS) MSCT (Light Speed VCT, GE) at 0.625 mm slice thickness, 0.35 s/rotation, tube 120 kV at 400 mA, ECG-gated for 4-D volumetric analysis, we used pulsating phantoms to measure end-diastolic (EDV) and end-systolic (ESV) volume and ejection fraction (EF) to assess reconstruction methods especially for higher pulsation rates.

Quantitative 4-dimensional volumetric analysis of left ventricle in ischemic heart disease by 64-slice computed tomography: a comparative study with invasive left ventriculogram.

Objective: To elucidate the usefulness of CT in evaluating left ventricular (LV) volumes and ejection fraction (EF) in ischemic heart disease (IHD), we compared 64-slice CT with conventional left ventriculography (CLVG).

Materials And Methods: 71 subjects with suspected or confirmed IHD underwent ECG-gated enhanced CT before or after cardiac catheterization. End-diastolic volume (EDV) and end-systolic volume (ESV) of LV were selected in 20 phases of R-R interval of ECG, and data sets were reconstructed to determine EDV, ESV, SV, and EF of LV using a multislice area summation method; in CLVG these parameters were calculated from the right anterior oblique 30-degree projection.

New acquisition method to exclusively enhance the left side of the heart by a small amount of contrast material achieved by multislice computed tomography with 64 data acquisition system.

Purpose: To exclusively enhance the left side of the heart by a small amount of contrast material (CM) using rapid acquisition of multislice computed tomography (MSCT) with a 64-data acquisition system (DAS).

Materials And Methods: Forty consecutive subjects underwent MSCT (Light Speed VCT, GE) with 0.625mm slice thickness to evaluate coronary arteries.