Synopsis of recent research by authors named "Makoto Saburi"
- Makoto Saburi's research predominantly focuses on the impact of maternal high-fat diets and social stress on cardiovascular disease (CVD) mechanisms, particularly through studying vascular remodeling and implications for insulin resistance and atherosclerosis development.
- Recent findings indicate that maternal high-fat diets not only promote calcified atherosclerotic plaque formation in adult offspring but also exacerbate abdominal aortic aneurysm expansion and insulin resistance through epigenetic and inflammatory pathways.
- Additionally, Saburi's work highlights the interplay between social stress and CVD, demonstrating that repeated social defeat can augment atherosclerosis and thrombus formation by enhancing neutrophil activity and altering fibrotic responses.
