Publications by authors named "Makoto Muto"

Article Synopsis
  • The study investigates the effectiveness of balloon pulmonary angioplasty (BPA) using intravascular ultrasound (IVUS) to treat total occlusion lesions in chronic thromboembolic pulmonary hypertension without using a conventional guidewire.* -
  • Out of 50 attempted cases, the initial success rate of the procedure was 54%, with the angle of the lesion being the key factor influencing success; post-procedural improvements in blood flow were noted even in 15 out of 23 initially unsuccessful cases.* -
  • The findings suggest that BPA can enhance peripheral blood flow post-procedure despite initial failures, and employing IVUS could be beneficial in optimizing treatment strategies for total occlusion lesions.*
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Background: Despite the effectiveness of the retrograde approach for chronic total occlusion (CTO) lesions, there are no standardized tools to predict the success of retrograde percutaneous coronary intervention (PCI).

Objectives: The aim of this study was to develop a prediction tool to identify CTO lesions that will achieve successful retrograde PCI.

Methods: This study evaluated data from 2,374 patients who underwent primary retrograde CTO-PCI and were enrolled in the Japanese CTO-PCI Expert Registry between January 2016 and December 2022 (NCT01889459).

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A 71-year-old woman was diagnosed with a tumor in the pancreatic head on CT imaging, which was performed as a close examination of an exacerbation of diabetes mellitus. The pancreatic tumor was diagnosed as resectable pancreatic cancer, and after preoperative adjuvant chemoradiotherapy, pancreatoduodenectomy was performed as a radical surgery. There were no residual tumor cells in the resected specimen histopathologically, and the patient was judged to have a pathological complete response(pCR).

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  • This study investigates the relationship between contrast media volume (CMV) and contrast-induced nephropathy (CIN) in patients with chronic kidney disease (CKD) undergoing percutaneous coronary intervention (PCI) for chronic total occlusion (CTO).
  • Results show that a minimum CMV of 50 mL or less significantly reduces the incidence of CIN compared to a higher CMV (1.0% vs. 4.1%, p = 0.03).
  • Additionally, patients in the minimum CMV group experienced higher success rates (96.8% vs. 90.3%) and fewer complications (3.1% vs. 7.1%) as well as a greater use of the
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The ability to engineer biologically viable hepatocytes and tissue matrices with long-term functional maintenance has attracted considerable interest in the fields of hepatocyte transplantation and liver tissue engineering. Here, newly developed hepatocyte sheets supplemented with adipose-derived stem cells (ADSCs) were evaluated to assess the effects of ADSCs on hepatocyte function and engraftment into the subcutaneous space. Eight-week-old male C57BL/6J mice were used as donors, and 6-week-old male C.

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In the transcatheter aortic valve implantation (TAVI) era, the indications for balloon aortic valvuloplasty (BAV) are increasing. Previously, the INOUE-BALLOON® (IB) was used only for antegrade BAV, but recently, it has also been used for retrograde BAV. However, the safety and feasibility of retrograde BAV using an IB are not fully understood.

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Balloon pulmonary angioplasty improves prognosis by alleviating pulmonary hypertension in patients with chronic thromboembolic pulmonary hypertension, even with incomplete revascularization. However, hypoxia or the requirement for pulmonary vasodilators often remain even after pulmonary hypertension relief. With this cohort study, we aimed to examine whether complete revascularization by additional balloon pulmonary angioplasty on residual lesions, even after pulmonary hypertension relief, could resolve hypoxia or the requirement for pulmonary vasodilators.

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Article Synopsis
  • - The study focused on identifying factors that predict prolonged guidewire manipulation time (GWMT) of 20 and 30 minutes during chronic total occlusion-percutaneous coronary intervention (CTO-PCI) using a primary antegrade approach.
  • - Analyzed data from 4,461 patients revealed nine anatomical characteristics, such as blunt stumps and calcification, as key predictors of prolonged GWMT, with increasing difficulty correlating to longer times.
  • - The findings suggest that understanding these predictive factors is crucial for planning CTO-PCI procedures and deciding when to switch to alternate approaches if necessary.
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A 45-year-old woman with abdominal pain after minor trauma was referred to our hospital. Computed tomography (CT) showed a hypovascular tumor in the left liver lobe. A tumor biopsy revealed granuloma, although no findings indicated malignancy or infection.

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The present case involved a 60-year-old man with autoimmune pancreatitis (AIP). While his AIP was in remission for 6 years, a follow-up CE-CT revealed a dilated main pancreatic duct (MPD) and an enhanced mural nodule. Fluorodeoxyglucose uptake was positive on positron emission tomography.

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Background: The relationship between the risk of right heart failure in primary acute pulmonary embolism after embolization and the residual thrombus sites in the pelvis and lower limbs is not clear.

Methods: This single-center retrospective observational study examined the results of contrast-enhanced computed tomography and venous ultrasonography of patients with primary acute PE and DVT. We assessed the association between the occurrence of right heart failure and age; gender; pulmonary thrombosis distribution; most proximal site of deep vein thrombosis in the soleal vein, inferior vena cava (IVC), or common iliac vein (CIV); DVT distribution; and malignancy using univariate and multivariate logistic regression.

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Background: Guidewire manipulation time is rarely used in chronic total occlusion (CTO) percutaneous coronary intervention (PCI) strategies.

Objectives: This study sought to develop an algorithm based on angiographic characteristics and guidewire manipulation time.

Methods: This study assessed 5,843 patients undergoing CTO PCI between January 2014 and December 2017 and enrolled in the Japanese CTO-PCI expert registry and analyzed their CTO-PCI strategies, procedural outcomes, and guidewire manipulation time.

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Article Synopsis
  • Two patients with pancreatic cancer—one receiving second-line treatment and the other third-line—were planned to be treated with FOLFIRINOX, despite both having UGT1A1 polymorphisms that increase the risk of toxicity from certain medications, including irinotecan.
  • FOLFIRINOX was administered cautiously, and even though both patients experienced Grade 4 neutropenia, it was managed effectively with G-CSF and dose adjustments.
  • No severe diarrhea or other serious side effects occurred, highlighting the need for more research on the use of FOLFIRINOX in patients with high-risk UGT1A1 polymorphisms.
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Objectives: We aimed to investigate strategies for reattempted percutaneous coronary interventions (PCIs) for chronic total occlusions (CTOs) by highly skilled operators after a failed attempt.

Background: Development of complex techniques and algorithms has been standardized for CTO-PCI. However, there is no appropriate strategy for CTO-PCI after a failed procedure.

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Aims: Guidewire (GW) tracking in a collateral channel (CC) is an important step during retrograde chronic total occlusion (CTO) percutaneous coronary intervention (PCI). The aim of this study was to create a prediction score model for CC GW crossing success.

Methods And Results: We analysed data on 886 CCs included in the Japanese CTO PCI Expert Registry during 2016.

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Background: Although annular pancreas concurrent with pancreaticobiliary maljunction has rarely been reported, some reports have pointed out a possibility that both anomalies have a common pathogenesis in pancreatic development. We herein report a case with pancreaticobiliary maljunction diagnosed long after surgical treatment for annular pancreas.

Case Presentation: A 34-year-old female, with a surgical history of duodenal obstruction due to annular pancreas in the neonatal period, was referred to our hospital for further examination of chronic pancreatitis.

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We hereby report a case of long-term survival of metastatic and recurrent duodenal gastrointestinal stromal tumor(GIST) treated with multimodality managements. A 59-year-old man was diagnosed with duodenal GIST and underwent surgical resection of a primary lesion of the duodenum. Since the pathological findings on mitotic rate indicated its high risk of recurrence, the systemic treatment by imatinib mesylate was given shortly after the surgery.

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We hereby report a case of long-term survival of the pancreatic tail cancer with a synchronous small liver metastasis. A 62- year-old male with pancreatic tail cancer was incidentally diagnosed with single tiny metastasis in the left medial section of the liver duringthe distal pancreatectomy. The lesion was also resected together with primary lesion.

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Objectives: This report describes the registry and presents an initial analysis of outcomes for the different PCI approaches taken by the specialists.

Background: Strategies for percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) are complex. The Japanese Board of CTO Interventional Specialists has developed a prospective, nonrandomized registry of patients undergoing CTO-PCIs performed by 41 highly experienced Japanese specialists.

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Objective: To investigate the short-term effects of infrapatellar fat pad (IFP) resection in normal dogs.

Study Design: Experimental in vivo study.

Animals: Five normal adult female beagle dogs.

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A 67-year-old man suffered from obstructive jaundice due to distal bile duct cancer. He underwent surgery after percutaneous biliary drainage and did not received adjuvant chemotherapy afterwards. Two years after surgery, some subcutaneous nodules were detected in the left axilla and the lateral chest on enhanced CT imaging.

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Article Synopsis
  • * Six months later, he developed multiple liver metastases and was diagnosed with AFP-producing gastric cancer.
  • * After surgery to remove the liver metastases, he experienced recurrences in the lung and remaining liver, but received chemotherapy and survived for an additional 15 months.
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