Clinical Significance of Early Computed Tomography Scan on Thrombus Regression Rate in Acute Pulmonary Embolism: Insights from the SAKURA PE/DVT REGISTRY.

Aims: Direct oral anticoagulants (DOACs) are used to treat venous thromboembolism (VTE). However, their impact on thrombus regression and the clinical outcomes after 2-week post-therapy computed tomography (CT) monitoring remains unexplored. This study aimed to elucidate the characteristics of patients with VTE treated with individual DOACs, assess the incidence of clinical events, and evaluate their impact on pulmonary artery thrombus regression.

Perceptual simultaneity range for two dichotically presented pure tones with frequency separation below 0.5 Bark.

The perceptual simultaneity range for two diotically presented tones increases with decreasing frequency separation of the two tones from approximately 0.5 Bark. As the present study of two frequency regions shows, this effect is not observed when the two tones are not presented to the same ear, i.

Emotional response evoked by viewing facial expression pictures leads to higher temporal resolution.

We examined the effects of emotional response, with different levels of valence and arousal, on the temporal resolution of visual processing by using photos of various facial expressions. As an index of the temporal resolution of visual processing, we measured the minimum lengths of the noticeable durations for desaturated photographs using the method of constant stimuli by switching colorful facial expression photographs to desaturated versions of the same photographs. Experiments 1 and 2 used facial photographs that evoke various degrees of arousal and valence.

Registry for Evaluating Healthy Life Expectancy and Long-Term Outcomes after Catheter Ablation of Atrial Fibrillation in the Very Elderly (REHEALTH AF) study: rationale and design of a prospective, multicentre, observational, comparative study.

Introduction: Data are lacking on the extent to which patients with non-valvular atrial fibrillation (AF) who are aged ≥80 years benefit from ablation treatment. The question pertains especially to patients' postablation quality of life (QoL) and long-term clinical outcomes.

Methods And Analysis: We are initiating a prospective, registry-based, multicentre observational study that will include patients aged ≥80 years with non-valvular AF who choose to undergo treatment by catheter ablation and, for comparison, such patients who do not choose to undergo ablation (either according to their physician's advice or their own preference).

Edoxaban Monotherapy in Nonvalvular Atrial Fibrillation Patients with Coronary Artery Disease.

Background: Current guidelines recommend an oral anticoagulant (OAC) monotherapy in patients with nonvalvular atrial fibrillation (NVAF) and stable coronary artery disease (CAD) 1 year postpercutaneous coronary intervention (PCI). It might be possible to shorten the time for de-escalation from a dual therapy to monotherapy, but data regarding de-escalation to an edoxaban monotherapy are lacking. This study aimed to assess the clinical safety of an edoxaban monotherapy in patients with NVAF and stable CAD.

New Hybrid Spikelet Sterility Gene Found in Interspecific Cross between and .

Various kinds of reproductive barriers have been reported in intraspecific and interspecific crosses between the AA genome species, to which Asian rice () and African rice () belong. A hybrid seed sterility phenomenon was found in the progeny of the cross between and , which is found in Northern Australia and Indonesia and has diverged from the other AA genome species. This phenomenon could be explained by an egg-killer model.

Clinical outcomes for intracoronary imaging strategies at different medical facilities in Japanese patients with coronary artery disease: the SAKURA imaging PCI Registry.

The relationships between intracoronary imaging modalities and outcomes among Japanese patients with coronary artery disease (CAD) based on the type of medical facility providing outpatient care remain unclear. In this multicenter prospective study (SAKURA PCI Registry), we aimed to investigate the clinical outcomes of patients with CAD who underwent percutaneous coronary intervention (PCI) between April 2015 and December 2018. In this registry, we investigated differences in patient characteristics, intracoronary imaging modalities, and clinical outcomes between two types of medical facilities.

Predicting individual emotion from perception-based non-contact sensor big data.

This study proposes a system for estimating individual emotions based on collected indoor environment data for human participants. At the first step, we develop wireless sensor nodes, which collect indoor environment data regarding human perception, for monitoring working environments. The developed system collects indoor environment data obtained from the developed sensor nodes and the emotions data obtained from pulse and skin temperatures as big data.

Perceived Duration Depends Upon Target Detection in Rapid Serial Visual Presentation Sequence.

It is well known that the perceived duration for a given time period decreases with the reduction of the number of perceived events. We examined whether target detection failures in viewing Rapid Serial Visual Presentation (RSVP) sequence, caused by attentional blink, affect this reduction of perceived duration. In two experiments, trials consisted of displays of two series of RSVP sequences; in the first sequence (the comparison), two, one, or no numerals were presented as targets embedded within the string of letters, while in the second sequence (the standard), only alphabetic letters were presented.

Zoledronate promotes inflammatory cytokine expression in human CD14-positive monocytes among peripheral mononuclear cells in the presence of γδ T cells.

Bisphosphonates distributed to bone exert toxic effects specifically towards osteoclasts. On the other hand, intravenous administration of a nitrogen-containing bisphosphonate (N-BP) such as zoledronate induces acute-phase reactions (APRs), including influenza-like fever 1 day later, indicating an interaction with immunocompetent cells circulating blood. Although it has been reported that activation of γδ T cells is pivotal to induce an APR following treatment with zoledronate, downstream events, including the production of inflammatory cytokines after activation of γδ T cells, remain obscure.

Enantioselectivity of 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Atropisomers toward Ryanodine Receptors (RyRs) and Their Influences on Hippocampal Neuronal Networks.

Nineteen ortho-substituted PCBs are chiral and found enantioselectively enriched in ecosystems. Their differential actions on biological targets are not understood. PCB 95 (2,2',3,5',6-pentachlorobiphenyl), a chiral PCB of current environmental relevance, is among the most potent toward modifying ryanodine receptors (RyR) function and Ca signaling.

Motion Capture Depends Upon the Common Fate Factor Among Elements.

When observers move the head backwards and forwards while fixating on the center of the concentric circles that consist of oblique lines, they see illusory rotation of those circles. If several dots are superimposed on the proximity to the inner concentric circles, observers see the illusory rotation not only for the circles but also for the superimposed dots. This illusory rotation of the dots is based on motion capture.

Visual Presentation Effects on Identification of Multiple Environmental Sounds.

This study examined how the contents and timing of a visual stimulus affect the identification of mixed sounds recorded in a daily life environment. For experiments, we presented four environment sounds as auditory stimuli for 5 s along with a picture or a written word as a visual stimulus that might or might not denote the source of one of the four sounds. Three conditions of temporal relations between the visual stimuli and sounds were used.

Awareness of Temporal Lag is Necessary for Motor-Visual Temporal Recalibration.

Consistent exposure to a temporal lag between observers' voluntary action and its visual feedback induced recalibration of temporal order perception between a motor action and a visual stimulus. It remains unclear what kinds of processing underlie this motor-visual temporal recalibration. This study examined the necessity of awareness of a temporal lag between a motor action and its visual feedback for motor-visual temporal recalibration.

Basis for motion capture in terms of illusory motion signal obtained from oblique lines.

As in the Pinna illusion, when an observer moves their head backwards and forwards while fixating on the center of concentric circles that consist of oblique lines, the observer sees illusory rotation of those circles. When several dots are superimposed on the concentric circles, an observer sees the illusory rotation not only for the circles, but also for those dots (Ichikawa, Masakura, & Munechika, 2006, Perception, 35, 933-946). This illusory rotation of the dots, which have no means of generating illusory motion themselves, is based on motion capture.

Effects of consciousness and consistency in manual control of visual stimulus on reduction of the flash-lag effect for luminance change.

Four experiments investigated how observers' consciousness about their control of stimulus change affects the visual perception associated with the illusory flash-lag effect. In previous study (Ichikawa and Masakura, 2006), we found that the flash-lag effect in motion is reduced if observers were conscious that they were controlling stimulus movements by the use of computer mouse, even if the stimulus moved automatically, independently of observer's mouse control. In the other study (Ichikawa and Masakura, 2010a), we found that the consistent directional relationship between the observer's mouse control and stimulus movement, which is learned in our everyday computer use, is important for the reduction of the flash-lag effect in active observation.

Non-retinotopic motor-visual recalibration to temporal lag.

Temporal order judgment (TOJ) between the voluntary motor action and its perceptual feedback is important in distinguishing between a sensory feedback which is caused by observer's own action and other stimulus, which are irrelevant to that action. Prolonged exposure to fixed temporal lag between motor action and visual feedback recalibrates motor-visual temporal relationship, and consequently shifts the point of subjective simultaneity (PSS). Previous studies on the audio-visual temporal recalibration without voluntary action revealed that the low level processing is involved.

Three-dimensional visualization of scoring mechanism of 'AngioSculpt' balloon for calcified coronary lesions using optical coherence tomography.

Despite developments in coronary interventional cardiology, plaque calcification is a critical issue of stent expansion. AngioSculpt Scoring Balloon Catheter (AngioSculpt; AngioScore Inc., Fremont, CA, USA) can produce more 'scoring' marks, which leads to prevention of 'plaque shift' and 'balloon slippage'; moreover, the 'scoring' produces some cutting effect, leading to successful stent implantation even on severe calcified lesions.

Angle illusion in a straight road.

We report a new angle illusion observed when viewing a real scene involving a straight road. The scene portrays two white lines which outline a traffic lane on a road and converge to a vanishing point. In experiment 1, observers estimated the angle created by these converging lines in this scene or in its image projected onto a screen.

Reduction of the flash-lag effect in terms of active observation.

In the present study, we investigated how observers' control of stimulus change affects temporal and spatial aspects of visual perception. We compared the illusory flash-lag effects for automatic movement of the stimulus with stimulus movement that was controlled by the observers' active manipulation of a computer mouse (Experiments 1, 2, and 5), a keyboard (Experiment 3), or a trackball (Experiment 4). We found that the flash-lag effect was significantly reduced when the observer was familiar with the directional relationship between the mouse movement and stimulus movement on a front parallel display (Experiments 1 and 2) and that, although the unfamiliar directional relationship between the mouse movement and stimulus movement increased the flash-lag effect at the beginning of the experimental session, the repetitive observation with the same unfamiliar directional relationship reduced the flash-lag effect (Experiment 5).

Murine metabolism and absorption of lancemaside A, an active compound in the roots of Codonopsis lanceolata.

Lancemaside A, a triterpenoid saponin isolated from the roots of Codonopsis lanceolata, has been reported to ameliorate the reduction of blood testosterone levels induced by immobilization stress in mice. In the present study, we investigated the metabolism and absorption of lancemaside A in mice. After oral administration of lancemaside A at 100 mg/kg body weight, the unmetabolized compound appeared rapidly in plasma (t (max) = 0.

Illusory temporal order for stimuli at different depth positions.

We used four experiments to examine how the perceived temporal order of two visual stimuli depends on the depth position of the stimuli specified by a binocular disparity cue. When two stimuli were presented simultaneously at different depth positions in front of or around a fixation point, the observer perceived the more distant stimulus before the nearer stimulus (Experiments 1 and 2). This illusory temporal order was found only for sudden stimulus presentation (Experiment 3).

Simultaneous determination of seven saponins in the roots of Codonopsis lanceolata by liquid chromatography-mass spectrometry.

We developed a rapid and simple analytical method for the simultaneous determination of seven 3,28-bidesmosidic triterpenoid saponins in the roots of Codonopsis lanceolata. The saponins are lancemaside A, lancemaside B, lancemaside C, lancemaside E, lancemaside G, foetidissimoside A, and aster saponin Hb. Root samples were extracted with 50% methanol and prepared for analysis.