Publications by authors named "Makota F"
Article Synopsis
- The text refers to a correction made to a previously published research article identified by its DOI: 10.1371/journal.ppat.1011517.
- Corrections in academic articles often address errors or inaccuracies in the original publication.
- This ensures that the scientific community has access to the most accurate and updated information related to the study.
Article Synopsis
- Apicomplexans are parasites like those causing malaria and toxoplasmosis, facing challenges with drug resistance and toxicity in current treatments.
- A new screening method using a Seahorse XFe96 flux analyzer identified six potential inhibitors targeting the mitochondrial electron transport chain (ETC) in T. gondii and Plasmodium falciparum.
- Two notable compounds, MMV024937 and MMV688853, could effectively combat drug-resistant parasites as they target the same ETC complex and have unique mechanisms of action.
Article Synopsis
- The mitochondrial electron transport chain (ETC) is essential for producing ATP and maintaining cell energy in many eukaryotic organisms, including parasites like apicomplexans.
- The ETC in these parasites differs from that in mammalian hosts, making it a potential target for drugs, such as atovaquone.
- The study introduces methods using a Seahorse XFe96 analyzer to measure oxygen consumption and metabolism in these parasites, allowing researchers to identify ETC functions and new inhibitors, particularly focusing on a unique protein, QCR11.
MHC class II (MHC II) Ag presentation by dendritic cells (DCs) is critical for CD4 T cell immunity. Cell surface levels of MHC II loaded with peptide is controlled by ubiquitination. In this study, we have examined how MHC II ubiquitination impacts immunity using mice expressing mutant MHC II molecules that are unable to be ubiquitinated.
View Article and Find Full Text PDFFollicular helper T (T) cells are a specialized subset of CD4 T cells that essentially support germinal center responses where high-affinity and long-lived humoral immunity is generated. The regulation of T cell survival remains unclear. Here we report that T cells show intensified lipid peroxidation and altered mitochondrial morphology, resembling the features of ferroptosis, a form of programmed cell death that is driven by iron-dependent accumulation of lipid peroxidation.
View Article and Find Full Text PDFFollicular helper T (T) cells control antibody responses by supporting antibody affinity maturation and memory formation. Inadequate T function has been found in individuals with ineffective responses to vaccines, but the mechanism underlying T regulation in vaccination is not understood. Here, we report that lower serum levels of the metabolic hormone leptin associate with reduced vaccine responses to influenza or hepatitis B virus vaccines in healthy populations.
View Article and Find Full Text PDFIron-sulfur (Fe-S) clusters are prosthetic groups on proteins that function in a range of enzymatic and electron transfer reactions. Fe-S cluster synthesis is essential for the survival of all eukaryotes. Independent Fe-S cluster biosynthesis pathways occur in the mitochondrion, plastid, and cytosolic compartments of eukaryotic cells.
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