Publications by authors named "Mako Otsuka"
Article Synopsis
- Pancreatic ductal adenocarcinoma (PDAC) has a very poor prognosis, and while some molecules are connected to its progression, many underlying mechanisms remain unclear.
- The study highlights that higher expression levels of Ror1 and Wnt5b—specific proteins—are linked to worse outcomes in PDAC patients and are notably found in PANC-1 cancer cells.
- Research shows that reducing levels of Ror1 or Wnt5b in these cells slows down their growth both in lab conditions and in live models, suggesting that the Wnt5b-Ror1 signaling pathway is crucial for the cancer's progression.
Article Synopsis
- * Further testing revealed a high presence of blast cells and basophils, indicating a problematic proliferation of certain blood cells.
- * The final diagnosis was acute monoblastic leukemia (M5a) along with secondary basophilic leukemia, highlighting the need to consider abnormal basophil levels in feline blood analysis.
Ror2 signaling has been shown to regulate the cell cycle progression in normal and cancer cells. However, the molecular mechanism of the cell cycle progression upon activation of Ror2 signaling still remains unknown. Here, we found that the expression levels of Ror2 in G1-arrested NIH/3T3 fibroblasts are low and are rapidly increased following the cell cycle progression induced by basic fibroblast growth factor (bFGF) stimulation.
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