Mechanics of wrinkle formation: micromechanical analysis of skin deformation during wrinkle formation in ultraviolet-irradiated mice.

Background/purpose: The mechanical aspects of wrinkle formation were studied in the dorsal skin of hairless mice.

Methods: Wrinkles were induced by irradiating with ultraviolet (UV) B for 10 weeks, while observing skin deformation during wrinkle formation. Changes in skin dimensions were also observed during the specimen excision process.