Publications by authors named "Makni M"

The study aims to investigate the residual and histopathological effects of chronic aluminum chloride (AlCl) toxicity in the kidney and liver of male rats. After 30-, 60-, and 90-day exposure period, analyses were conducted to assess the toxicity in the kidney and liver. The results showed that the concentration of AlCl in the kidney and liver increased significantly in 30-, 60-, and 90-day periods.

View Article and Find Full Text PDF

Introduction: Eighty-five per cent of uterine inversions are puerperal. Non-puerperal uterine inversion is usually caused by tumours that exert a traction force on the fundus of the uterus. This causes the uterus to be partially or completely inverted.

View Article and Find Full Text PDF

Our study aimed to analyze five monovarietal honeys from the Salah Eddine region in Iraq, focusing on physicochemical, antioxidant, and antimicrobial properties and polyphenolic compounds. Our objective was to evaluate the strengths and qualities of Iraqi honeys, ensuring compliance with the Codex Alimentarius standard for honey. The spectrophotometric analysis included assessments of reduced sugar (75.

View Article and Find Full Text PDF

In natural populations, hybridization is known to occur between a wide range of species. However, its evolutionary significance is less clear. Genes involved in fighting pathogens are considered excellent candidates for studying adaptive introgression, although both introgression and balancing selection can generate similar patterns of diversity and differentiation.

View Article and Find Full Text PDF

The COVID-19 outbreak has hit enterprises all around the world, affecting virtually every business area and industry. Consequently, the purpose of this paper is to investigate how COVID-19 has affected the performance of listed companies in the Saudi market. The study uses financial data from 2009 to 2019 to examine the performance of the listed Saudi firms.

View Article and Find Full Text PDF

Introduction: embryo implantation is a crucial step for assisted reproductive technology (ART) achievement. Human chorionic gonadotropin (hCG) is one of the main regulators of the implantation process. Studies focusing on the impact of intrauterine hCG infusion at the time of embryo transfer on clinical ART outcomes have shown controversial results, mainly at blastocyst stage.

View Article and Find Full Text PDF

Background And Aim: Propolis has a protective effect against cellular damage caused by toxic agents such as drugs, metals, xenobiotics, and chemicals. The aim of this study was to investigate the antioxidant activity and the effect of ethanolic extract of propolis on carbon tetrachloride (CCl4)-induced oxidative stress on kidney and liver injury in rat.

Materials And Methods: The study quantified phenol, flavone, and flavonol in propolis and assessed antioxidant activity using 2, 2-diphenyl-1-picrylhydrazyl, ferric reducing antioxidant power, and molybdate.

View Article and Find Full Text PDF
Article Synopsis
  • There is a new amendment related to the paper that has been published.
  • This amendment can be found through the original article.
  • The changes or updates made in the amendment are important for understanding the context of the original work.
View Article and Find Full Text PDF

Background: Although native to North America, the invasion of the aphid-like grape phylloxera Daktulosphaira vitifoliae across the globe altered the course of grape cultivation. For the past 150 years, viticulture relied on grafting-resistant North American Vitis species as rootstocks, thereby limiting genetic stocks tolerant to other stressors such as pathogens and climate change. Limited understanding of the insect genetics resulted in successive outbreaks across the globe when rootstocks failed.

View Article and Find Full Text PDF
Article Synopsis
  • - Men with non-obstructive azoospermia (NOA) can potentially have viable sperm in their testes, and advanced sperm retrieval techniques like microdissection testicular sperm extraction (mTESE) are essential for improving fertility, with a sperm retrieval rate (SRR) of 60%.
  • - A study conducted on 1,050 NOA patients using a modified mTESE technique with 6-fold magnifying loupes resulted in finding sperm in 61% of cases on the first testis and increased the overall SRR from 43% to 51.8%.
  • - This modified mTESE technique is effective and reliable for institutions lacking an operating microscope, making it particularly beneficial for patients with
View Article and Find Full Text PDF
Article Synopsis
  • Male infertility is a significant health issue, with multiple morphological abnormalities of the flagella (MMAF) being a severe form that causes asthenozoospermia due to irregular sperm flagella.
  • Six genes linked to MMAF have been identified; however, many cases remain unexplained, indicating more undiscovered gene defects.
  • Whole-exome sequencing revealed that mutations in the ARMC2 gene cause the MMAF phenotype in both humans and mice, highlighting its crucial role in sperm flagellum structure and assembly.
View Article and Find Full Text PDF

Background: High-risk human papillomavirus (HPV) types are the main etiological factors for cervical cancer. HPV16 and HPV18 are generally the most common forms associated with development of high-grade cervical lesions. This study was undertaken to identify intratypic variants of HPV16 and HPV18 among women with cervical lesions in Tunisia.

View Article and Find Full Text PDF

In this study, a systematic analysis of Nucleotide-Binding Site (NBS) disease resistance () gene family in the barley, L. cv. Bowman, genome was performed.

View Article and Find Full Text PDF

Background/aim: Various honey samples exhibited protective effect against drug and chemical induced toxicity. The study was designed to determine the antioxidant content and activity of carob honey and to investigate its hepato-renal protective effect in carbon tetrachloride (CCl4) induced kidney and liver injury in rats.

Material And Methods: Phenolic, flavone and flavonol in carob honey were quantified.

View Article and Find Full Text PDF
Article Synopsis
  • Multiple morphological abnormalities of the sperm flagellum (MMAF) is a serious male infertility issue characterized by various sperm flagella defects, linked to genetic mutations affecting axonemal proteins.
  • Researchers analyzed whole-exome sequencing data from 78 affected individuals and discovered a homozygous deletion in the WDR66 gene in 7 cases, indicating a new genetic contributor to MMAF.
  • Further experiments, including studies on a related protein in Trypanosoma, demonstrated that this gene deletion impairs flagellar movement, thus confirming WDR66's role in male infertility related to MMAF.
View Article and Find Full Text PDF

In natural populations, allelic diversity of the major histocompatibility complex (MHC) is commonly interpreted as resulting from positive selection in varying spatiotemporal pathogenic landscapes. Composite pathogenic landscape data are, however, rarely available. We studied the spatial distribution of allelic diversity at two MHC class II loci (DQA, DQB) in hares, Lepus capensis, along a steep ecological gradient in North Africa and tested the role of climatic parameters for the spatial distribution of DQA and DQB proteins.

View Article and Find Full Text PDF

Toll-like receptors (TLRs) are a major group of proteins that recognize molecular components of infectious agents, known as pathogen associated molecular patterns (PAMPs). The structure of these genes is similar and characterized by the presence of an ectodomain, a signal transmembrane segment and a highly conserved cytoplasmic domain. The latter domain is homologous to the human interleukin-1 receptor (IL1R) and human IL-18 receptor (IL-18R) and designated TIR domain.

View Article and Find Full Text PDF
Article Synopsis
  • The genetic basis of oocyte meiotic deficiency (OMD), a primary infertility issue linked to immature egg production, is under-researched.
  • A study using whole exome sequencing revealed that 26% of individuals with OMD carried the same harmful mutation in the PATL2 gene, which is thought to be crucial for RNA regulation.
  • Experiments with knockout mice indicated that the absence of PATL2 disrupts oocyte development and maturation by affecting key gene expressions, establishing PATL2 as an important factor in mammalian fertility.
View Article and Find Full Text PDF

Natural plant extracts contain a variety of phenolic compounds which are assigned various biological activities. Our work aims to make a quantitative and qualitative characterization of the Zest (ZL) and the Flesh (FL) of lemon , to valorize the pharmacological uses of lemon, by evaluating activities (DPPH, free radical scavenging and reducing power). The antibacterial, antifungal, and antiproliferative activities were sought in the ability of extracts to protect DNA and protein.

View Article and Find Full Text PDF
Article Synopsis
  • Spermatogenesis issues affect millions of men globally, but many remain undiagnosed.
  • The research identified 22 men with primary infertility linked to mutations in genes DNAH1, CFAP43, and CFAP44, confirmed through genetic sequencing.
  • CRISPR/Cas9 experiments on mice demonstrated that CFAP43 and CFAP44 are crucial for producing functional sperm flagella, underscoring their importance across different species.
View Article and Find Full Text PDF

Physicochemical properties, main mineral content, and antioxidant activity were determined for eight floral carob honeys collected from different geographical regions of Morocco. Moroccan honeys showed good chemical and nutritional qualities, fulfilling the criteria described in the standard codex for honey. The percentages obtained for ashes were (0.

View Article and Find Full Text PDF
Article Synopsis
  • The R81T mutation, which leads to resistance against neonicotinoid insecticides in the aphid species Myzus persicae, has spread notably through southern Europe and was recently studied in Tunisia.
  • In Tunisia, the mutation was found at significant levels (32-55%) in northern regions but was less common in the south, appearing in aphids from key crops like peach, potato, and tomato.
  • This finding marks the first detection of the R81T mutation in North Africa and highlights a threat to effective aphid control, necessitating further research into the management of resistant populations.
View Article and Find Full Text PDF

Background: Recently, probiotics have increasingly been used as feed additives in poultry diets as an alternative to antibiotic growth promoters fostering resistance development.

Results: This study was aimed at assessing the potential of Bacillus amyloliquefaciens US573 as a direct-fed microbial. The US573 strain was found to be free of harmful enzymatic activities and sensitive to antibiotics.

View Article and Find Full Text PDF

Background: Although transposons have been identified in almost all organisms, genome-wide information on mariner elements in Aphididae remains unknown. Genomes of Acyrthosiphon pisum, Diuraphis noxia and Myzus persicae belonging to the Macrosiphini tribe, actually available in databases, have been investigated.

Results: A total of 22 lineages were identified.

View Article and Find Full Text PDF