[Immunoregulatory proteins and cytokines in the blood of patients with Graves' disease].

Background: Immunoregulatory proteins (alpha-2-macroglobulin, lactoferrin) actively participate in inflammatory and autoimmune processes, affect synthesis and transport of hormones and cytokines, and control cell proliferation and apoptosis. However, the role of these proteins in the pathogenesis of Graves' disease (GD) is poorly understood. Objective - the study objective was to determine blood levels of alpha-2-macroglobulin (α2-MG), lactoferrin (LF), and cytokines (TNF-α, IL-6, IL-8, and IFN-γ) in GD.

[Group preventive consultation of the population concerning nutrition. Experience of School of the balanced nutrition founded on the basis of the Health center].

The development of the program of group preventive consultation of visitors of the centers of health concerning nutrition and assessment of its efficiency was the purpose of the work. The analysis of the results of inspection of 2569 visitors of the Health сenter at the age of 18–78 years and randomized, open, cross research of 242 women (27–72 years old) who passed group preventive consultation in the Center of health at «School of a balanced nutrition » were carried out. Anthropometrical data and the actual nutrition with use of the computer program «Analysis of the Person Nutrition» were studied.

[The concentrations of certain cytokins and lactoferrin in blood and supernatants of cell cultures in patients with autoimmune thyroiditis].

The analysis was applied to serum and supernatants of day cultures of blood cells of patients with autoimmune thyroiditis and healthy women to determine the content of cytokins (IFN-gamma, TNF-alpha, IL-beta, IL-6, IL-10, L-17) and lactoferrin. The test-system "Cytokin-Stimul-Best" was applied. It is established that in patients with autoimmune thyroiditis the proliferative response of cells to mitogen stimulation is lowered in vitro: the levels of alpha-tumor necrosis factor interleikin-6, lactoferrin.

[Hormones, cytokines and macroglobulines in blood of women with autoimmune thyroid diseases].

Aim: To study proportions of hormones, cytokines and macroglobulins in autoimmune thyroid diseases.

Material And Methods: Participants of the study were 28 females aged 43 +/- 5 years with diffuse toxic goiter (DTG), 31 females aged 41 +/- 6 years with autoimmune thyroiditis (AIT) and 26 controls (n = 26) free of thyroid pathology aged 40 +/- 4 years. DTG and AIT diagnoses were confirmed by ultrasound and laboratory examinations.