Publications by authors named "Maki Obata"
Postmortem research participation remains underrepresented in research ethics discussions. Herein, we examined the associated perspectives of individuals preregistered with the Brain Bank for Aging Research at the Tokyo Metropolitan Institute of Gerontology. We conducted a postal survey targeting 88 preregistrants, yielding 52 responses (response rate: 59.
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- A case study focused on a 71-year-old woman with right temporal variant frontotemporal dementia (rtvFTD) revealed significant heading disorientation, showing that neurodegenerative diseases might impact spatial navigation differently than cerebrovascular diseases.
- Despite preserved general cognition, the patient struggled with familiar environments, unable to draw routes or maps, although she recognized landmarks; neuropsychological tests indicated specific heading disorientation related to her condition.
- Imaging studies (MRI and PET) showed notable abnormalities in the right hemisphere, especially in the retrosplenial region, which is linked to heading disorientation, and the patient’s symptoms worsened over time, which is distinct from prior observations with cerebrovascular cases.
Dynorphin induced magnetic ordering in lipid bilayers as studied by (31)P NMR spectroscopy.
Biochim Biophys Acta
January 2002
Lipid bilayers of dimyristoyl phosphatidylcholine (DMPC) containing opioid peptide dynorphin A(1-17) are found to be spontaneously aligned to the applied magnetic field near at the phase transition temperature between the gel and liquid crystalline states (T(m)=24 degrees C), as examined by 31P NMR spectroscopy. The specific interaction between the peptide and lipid bilayer leading to this property was also examined by optical microscopy, light scattering, and potassium ion-selective electrode, together with a comparative study on dynorphin A(1-13). A substantial change in the light scattering intensity was noted for DMPC containing dynorphin A(1-17) near at T(m) but not for the system containing A(1-13).
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