Publications by authors named "Makheni Jean Pierre"

Article Synopsis
  • IL-22 plays a crucial role in reducing metabolism issues caused by obesity, but its specific action sites are unclear.
  • Researchers created mice with specific IL-22RA1 knockouts in the intestine, liver, and white adipose tissue to study its effects on metabolism when on a high-fat diet.
  • Findings reveal that IL-22RA1 signaling in the intestine and liver improves glucose metabolism and influences fat tissue metabolism, highlighting the significance of gut signaling in managing obesity-related metabolic disorders.
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Biologically active small molecules can impart modulatory effects, in some cases providing extended long-term memory. In a screen of biologically active small molecules for regulators of tumor necrosis factor (TNF) induction, we identify several compounds with the ability to induce training effects on human macrophages. Rutaecarpine shows acute and long-term modulation, enhancing lipopolysaccharide (LPS)-induced pro-inflammatory cytokine secretion and relieving LPS tolerance in human macrophages.

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Article Synopsis
  • Previous research highlights the role of IL-17A in regulating gut microbiota and overall metabolic functions, but the specific site of IL-17RA signaling has not been explored.
  • Using specific mouse models that lack IL-17RA in either the intestines or liver, the study found that gut IL-17RA signaling is crucial for managing metabolic functions when exposed to a high-fat diet.
  • Mice lacking intestinal IL-17RA exhibited negative effects like poor glucose metabolism, abnormal hormone levels, increased body fat, and greater liver fat accumulation, linking changes in gut microbiota to systemic glucose regulation.
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