Simultaneous determination of cyclodol and diprazin by thin layer chromatography and high performance liquid chromatography.

Ciklodol (trihexyphenidil)--the central and peripheral m-cholinoblocker is currently used with other antipsychotic drugs such as phenotiazines and tricycle antidepressants. For the purpose of simultaneous determination of ciklodol and diprazine, were selected two methods of analysis: Thin Layer Chromatography (TLC) and High Performance Liquid Chromatography (HPLC). During development of TLC method was studied the 10 visualizing system and 24 mobile systems.

[Using of chromatographical methods to study stability, pharmacokinetics and metabolism of propofol (review)].

Propofol (somnopol, diprivan) 2,6-diisoprophilphenol is a preparation of short-term, intravenous narcosis used for local and general anaesthesia through single injection or permanent infusion with the speed of 4-12 mg/kg in an hour. In this study we tried to summarize the experience of using of chromatographical methods (gas chromatography-GCH0, high performance liquid chromatography (HPLC), thin layer chromatography (TLCH) and combination of mass-spectrometry with GCH (GCH-MC) and HPLC (HPL-MC) to study stability, pharmacokinetics and metabolism of propofol. A labour-intensive and important work have been carried out to obtain information about propofol.

[Investigation of conjugation and metabolism of propofol with the method of high performance liquid chromatography].

Propophol (somnopol, diprivan) is widely used in medicine for local and general narcosis through single injection or permanent infusion. Study of conjugation and metabolism of medications is considered as question of great importance, especially for substances used at anaesthesia. To study the above-mentioned questions the total complex of methods of chromatographical analysis, especially, high performance liquid chromatolgraphy (HPLC), are widely used.

[New methods of chemical and toxicological study of clonidine (Clophelinum)].

Clophelinum (clonidine) has hypotensive and soothing effect. The literature describes cases of a poisoning with clonidine, the majority of which are of the criminal character. Symptoms of clonidine intoxication differ from poisoning with other substances.

[Clinical significance of genetically determined polymodality of the distribution of quinidine elimination rates].

A population study of quinidine half-elimination time distribution has demonstrated a trimodality of distribution that is due to different rates of metabolic quinidine oxidation. The ratio of permanent serum concentrations of 3-oxyquinidine (metabolite) to quinidine in the rapid oxidation group was elevated significantly, as compared to slow oxidation groups. The values obtained in these phenotypic groups show good correspondence to the Hardy-Weinberg law, with a 0.