Publications by authors named "Makena Clive"
Article Synopsis
- * Preclinical experiments showed that entinostat enhances the effectiveness of olaparib by reducing cell survival and promoting DNA damage in ovarian cancer cells, leading to reduced peritoneal metastasis in animal models.
- * Overall, the research suggests that entinostat could inhibit HR repair mechanisms and worsen genome stability, providing strong preclinical support for a clinical trial investigating the effectiveness of this drug combination in patients with HR-proficient ovarian cancer, including those with CCNE1
The oxytocin receptor (OXTR) is a key regulator of stress and anxiety and may be regulated by both psychosocial risk factors and gonadal hormones, making it an attractive candidate for study in postpartum depression (PPD). The objective of this study was to investigate both serum hormone and PPD specific DNA methylation variation in the OXTR. Illumina HM450 microarray data generated in a prospective PPD cohort identified significant associations (P=0.
View Article and Find Full Text PDFDNA methylation variation at HP1BP3 and TTC9B is modified by estrogen exposure in the rodent hippocampus and was previously shown to be prospectively predictive of postpartum depression (PPD) when modeled in antenatal blood. The objective of this study was to replicate the predictive efficacy of the previously established model in women with and without a previous psychiatric diagnosis and to understand the effects of changing hormone levels on PPD biomarker loci. Using a statistical model trained on DNA methylation data from N=51 high-risk women, we prospectively predicted PPD status in an independent N=51 women using first trimester antenatal gene expression levels of HP1BP3 and TTC9B, with an area under the receiver operator characteristic curve (AUC) of 0.
View Article and Find Full Text PDF