In vivo regeneration functionalities of experimental organo-biomaterials containing water-soluble nacre extract.

Background: Novel multifunctional biomaterials were recently designed to allow for an optimized tissue regeneration process.

Purpose: To comprehensively assess (photographic, radiographic and histological) the in vivo functionality of demineralized bovine bone matrix (DBM) associated with an experimental marine organic extract (MOE) from nacre in a sheep ectopic grafting model.

Materials And Methods: Synthesis of MOE was based on mixing powdered nacre (0.