Publications by authors named "Makayla Standfest"
J Appl Oral Sci
October 2024
Article Synopsis
- The study aimed to explore the effectiveness of phosphonoformic acid (PFA) and Dynasore in preventing medication-related osteonecrosis of the jaw by blocking bisphosphonates' entry into human gingival fibroblasts (HGFs).
- The researchers found that while PFA did not protect HGFs from the harmful effects of zoledronate (ZOL), Dynasore successfully prevented cell death when exposed to ZOL and inhibited the macropinocytosis process.
- Overall results indicated that Dynasore was effective in blocking ZOL entry and preventing endosomal acidification, suggesting it could be a potential treatment option for managing medication-related osteonecrosis of the jaw.
