Publications by authors named "Makayla Hourihan"
Article Synopsis
- Schizophrenia's complexity has made it difficult to understand its mechanisms and develop effective treatments; a new study addresses this by examining transcriptomic changes at the single-cell level in the human prefrontal cortex of 140 individuals.
- The researchers found that excitatory neurons were the most affected, with changes related to neurodevelopment and synapse function, and identified both common and rare genetic risk factors influencing these neuronal alterations.
- Their findings reveal two distinct groups of individuals with schizophrenia based on specific excitatory and inhibitory neuron states, linking genetic risk to cellular changes and enhancing our understanding of schizophrenia's underlying biology.
