Efficacy and Safety of Amivantamab in Advanced or Metastatic EGFR-Mutant Non-Small Cell Lung Cancer: A Systematic Review.

This systematic review aimed to examine the efficacy and safety profile of amivantamab in patients with advanced or metastatic non-small cell lung cancer (NSCLC) and EGFR mutations. Three scientific databases, PubMed, Cochrane library and ClinicalTrials.gov were searched for relevant articles up until 30 June 2024.

Particulate bioaerogels for respiratory drug delivery.

The bioaerogel microparticles have been recently developed for respiratory drug delivery and attract fast increasing interests. These highly porous microparticles have ultralow density and hence possess much reduced aerodynamic diameter, which favour them with greatly enhanced dispersibility and improved aerosolisation behaviour. The adjustable particle geometric dimensions by varying preparation methods and controlling operation parameters make it possible to fabricate bioaerogel microparticles with accurate sizes for efficient delivery to the targeted regions of respiratory tract (i.

Highly efficient poly(acrylic acid-co-aniline) grafted itaconic acid hydrogel: Application in water retention and adsorption of rhodamine B dye for a sustainable environment.

The present study used a free radical co-polymerization approach to synthesize a smart hydrogel of itaconic acid grafted poly(acrylic acid-co-aniline) (ItA-g-poly(AA-co-ANi)). ItA-g-poly(AA-co-ANi) hydrogel was characterized by Fourier transform infrared spectroscopy (FT-IR), Raman, X-ray diffraction (XRD), thermogravimetric analysis (TGA), field emission scanning electron microscope (FE-SEM), and X-ray photoelectron spectroscopy (XPS) analysis. Rhodamine B (RhB) dye was removed from an aqueous medium using ItA-g-poly(AA-co-ANi) hydrogel.

Valorisation of algal biomass to value-added metabolites: emerging trends and opportunities.

Algal biomass is a promising feedstock for sustainable production of a range of value-added compounds and products including food, feed, fuel. To further augment the commercial value of algal metabolites, efficient valorization methods and biorefining channels are essential. Algal extracts are ideal sources of biotechnologically viable compounds loaded with anti-microbial, anti-oxidative, anti-inflammatory, anti-cancerous and several therapeutic and restorative properties.

Synthesis and characterisation of zinc oxide modified biorenewable polysaccharides based sustainable hydrogel nanocomposite for Hg ion removal: Towards a circular bioeconomy.

Industrial metal ion pollution has been considered the chief source of water contaminants all over the world. In the present research, we have prepared gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide (GT-cl-(HEMA-co-AAm)) hydrogel and gum tragacanth cross-linked 2-hydroxyethyl methacrylate-co-acrylamide/zinc oxide (GT-cl-(HEMA-co-AAm)/ZnO) hydrogel composite with better Hg adsorption capability. GT-cl-(HEMA-co-AAm)/ZnO hydrogel composite (154.

Effects of the homopolymer molecular weight on a diblock copolymer in a 3D spherical confinement.

The morphologies of a diblock copolymer spherically confined within a homopolymer were investigated by using the static self-consistent field theory method. A homogeneous - diblock copolymer sphere was surrounded by a homopolymer . Upon changing the diblock volume fraction, homopolymer molecular weight and the interaction between the copolymer and its surrounding environment, different morphologies of the sphere were observed.

Directed Assembly Network phase three launch: a round-up of success to date and strategy for the future.

To showcase the Networks' success during phase two (2012-2016), and to set out the strategy for phase three (2017-2019), the Directed Assembly Network held a meeting at the Royal Society in London, United Kingdom on 14 and 15 December 2016. Seventy Network members from both industry and academia attended the event. The meeting, which was used as a springboard to launch and distribute the Networks' 2017 Roadmap to Innovation, comprised of invited talks, an advisory committee meeting, a panel Q & A session and networking.

A flow-system array for the discovery and scale up of inorganic clusters.

The batch synthesis of inorganic clusters can be both time consuming and limited by a lack of reproducibility. Flow-system approaches, now common in organic synthesis, have not been utilized widely for the synthesis of clusters. Herein we combine an automated flow process with multiple batch crystallizations for the screening and scale up of syntheses of polyoxometalates and manganese-based single-molecule magnets.

FGFR3 related skeletal dysplasias diagnosed prenatally by ultrasonography and molecular analysis: presentation of 17 cases.

Fibroblast Growth Factor Receptor 3 (FGFR3) related skeletal dysplasias are caused by mutations in the FGFR3 gene that result in increased activation of the receptors causing alterations in the process of endochondral ossification in all long bones, and include achondroplasia, hypochondroplasia, thanatophoric dysplasia, and SADDAN. Reports of prenatal diagnosis of FGFR3 related skeletal dysplasias are not rare; however, the correlation between 2nd trimester ultrasonographic findings and underlying molecular defect in these cases is relatively poor. There is a need for specific ultrasound (U/S) predictors than can distinguish lethal from non-lethal cases and aid an earlier prenatal diagnosis.

First principles studies of an Si tip on an Si(100)2 × 1 reconstructed surface.

We present a systematic study of the interaction between a silicon tip and a reconstructed Si(100)2 × 1 surface by means of total energy calculations using density functional theory. We perform geometry optimization to obtain the reconstructed Si surface using the local density approximation and the generalized gradient approximation methods and compare our results with those obtained experimentally. We then study the effects of the tip of a scanning probe of an atomic force microscope (AFM) on the behaviour of atoms on the reconstructed surface when the tip translates at distances close to it.

Prenatal diagnosis of hypochondroplasia: report of two cases.

Hypochondroplasia (HCH) is an autosomal dominant skeletal dysplasia characterized by short extremities, short stature and lumbar lordosis, usually exhibiting a phenotype similar to but milder than achondroplasia (ACH). Mutations in the fibroblast growth factor receptor 3 (FGFR3) gene are present in a significant proportion of HCH patients. Reports of prenatal diagnosis of HCH are very rare and the phenotype/genotype correlation in these patients is poor.

Prenatal diagnosis of achondroplasia presenting with multiple-suture synostosis: a novel association.

Objective: We report an atypical case of a fetus presenting with a combined achondroplasia and multiple craniosynostosis phenotype.

Methods: Sonographic monitoring in conjunction with molecular genetic analysis was performed in a 32-gestational weeks fetus.

Results: Sonographic findings were consistent with a diagnosis of achondroplasia associated with multiple-suture synostosis.

A simple and effective approach for detecting maternal cell contamination in molecular prenatal diagnosis.

The presence of maternal cells in fetal samples constitutes a serious potential source for prenatal misdiagnosis. Here we present our approach for detecting maternal cell contamination (MCC) at prenatal diagnosis for eight monogenic disorders (autosomal recessive: beta-thalassaemia, sickle-cell anaemia, cystic fibrosis, prelingual deafness; autosomal dominant: achondroplasia, Huntington disease, myotonic dystrophy, neurofibromatosis type I; X-linked: spinobulbar muscular atrophy). Our aim was to apply a simple and low-cost approach, which would easily and accurately provide information on the fetal tissue MCC status.