[Superoxide dismutase in liver ischemia].

The properties of Cu,Zn-superoxide dismutase (SOD) from rat liver after 2-hour total ischemia or after ischemia with subsequent 24-hour reperfusion were studied. Two hours after ischemia the specific activity of SOD decreases drastically (about 3-fold) - from 510 +/- 11 u./mg in normal tissue and 196 +/- 33 u.

[The rehabilitation of patients with pulmonary tuberculosis in combination with chronic nonspecific lung diseases].

One hundred and fifty five patients with pulmonary tuberculosis concurrent with chronic nonspecific pulmonary diseases (most commonly chronic obstructive bronchitis) were examined. The analysis of the obtained material has indicated that with a combined affection, an early development of respiration and blood circulation dysfunction is observed. In addition, some patients often continue to work in contraindicated labor conditions, which leads to serious disability with low rehabilitative potentialities.

[Sensitivity of phagocytes in the blood and bronchoalveolar tract to hydrocortisone in acute injury of the respiratory organs].

Pneumonia was modelled in experiments on female hybrid mice (CBA X C57Bl)F1 by intratracheal administration of 0.1 ml of 0.4% AgNO3 solution.

[Dynamics of immunologic indicators in stomach ulcer].

Time course of cellular and humoral immunity parameters in the course of ulcer defect healing was followed up in 47 patients with gastric ulcers. Immune status changes in these patient population were found dependent on the stage of ulcer defect healing, being the most manifest at the beginning of ulcer cicatrization and showing signs of immune system activation. A possible relationship between changes in the immunity status and reparative processes at the site of ulcer defect is discussed.

[The health status and the indices of urinary system activity in children with long-term exposure to drinking water with an adverse mineral content].

A study was made of the effect of drinking highly mineralized water on the children's health status, particularly on the urinary system activity. As many as 357 children living in one of the poorly irrigated regions of the Saratov land along the Volga were examined. It has been established that drinking highly mineralized water is a high-intensity factor producing an untoward effect on the children's physical development, contributing to the rise of the incidence of acute (mainly respiratory) and chronic diseases (cholecystopathies, nephropathies, gastrointestinal diseases, nocturnal enuresis, dental caries).

[The effect of hydrocortisone on neutrophil functional activity].

The male (CBA X C57BL) FI mice received 125 mg of hydrocortisone per kg body weight intraperitoneally. The functional activity of neutrophils has been evaluated by means of nitroblue terazolium test (NBT-test) values taken before or after heat-killed S. marcescens cell stimulation in vitro by 2, 12, 24 h 3, 7 or 14 days post hormonal treatment.

[Indicators of cellular and humoral immunity during the process of healing of stomach ulcer].

Cellular and humoral immunity parameters in the process of healing of ulcer were studied in 47 patients with gastric ulcer. Changes in the immune status in these patients depended on the stage of healing of an ulcerous defect (active exacerbation, the beginning of cicatrization, "red" or "white" scar) and were most pronounced at the initial period of ulcer cicatrization. They were manifested by the signs of the immune system activation (primarily by increase in the relative content of theophylline-resistant T-lymphocytes).

[Morphology and pathogenesis of chronic bronchitis].

Histologic and ultrastructural features of the chronic catarrhal bronchitis are presented and its pathogenetic mechanisms are discussed. An important role in the development of bronchitis of the mucociliary transport system damage, retention of the mucus and bacterial contamination of the respiratory tract is analysed. Current hypothesis of the chronic bronchitis development based on the disturbance of the protease-antiprotease and oxidative-antioxidative balance is presented.

[The cytological characteristics of bronchoalveolar washings in chronic bronchitis].

Bronchoalveolar washings (BAWs) from 30 patients with nonobstructive chronic bronchitis (CB) were examined cytologically. On the basis of the taxonomic analysis of the data on the cytological examination of the BAWs, all the observations were classified as belonging to degrees I, II and III of the cytological activity of the inflammatory process in the lungs. It was revealed that the minimal degree of the activity of the inflammatory process was characterized by a marked increase in the relative numbers of the cells of the desquamated cylindrical epithelium and destroyed cells along with a significant decrease in the proportion of macrophages and an increase in the relative count of neutrophils.

[Clinical, cytological and immunological characteristics of the effect of ENKAD on the mouth mucosa in Sjögren's syndrome].

A study of the clinical efficacy and the immunomodulating and antiinflammatory effect of ENCAD was conducted in 20 patients with Sjogren's disease (SD) of various degrees of activity of oral mucosa involvement and in a group of 23 healthy controls, with a saline solution as placebo. ENCAD was shown to lessen the expression of the clinical symptoms of xerostomia in both groups of a low and a moderate and high degrees of local activity of an inflammatory process. A tendency to the normalization of regeneration and desquamation in the oral mucosa epithelium was observed against a background of the reduction of an inflammatory reaction.

[The immune system of the lungs in healthy subjects and in chronic nonspecific diseases].

Resistance of lung to the action of damaging factors is determined by the mechanisms of non-specific defence and immunologic responseveness that is expressed by systemic and local immune reactions. Local immune response in bronchi is brought about by a lymphoid tissue associated with bronchi. Alveolar macrophages carry out a main protective function in the respiratory parts.

Antibodies to nucleic acids in systemic lupus erythematosus and rheumatoid arthritis patients and their relatives.

Sera of systemic lupus erythematosus (SLE) patients contain antibodies to double-stranded and single-stranded DNA while antibodies found in rheumatoid arthritis sera are specific mainly to single-stranded DNA. Anti-RNA antibodies in the both cases are directed against double-stranded RNA and belong to the IgM class while anti-DNA antibodies are IgG. Genetic variance analysis based on family correlations suggests that the synthesis of antibodies to DNA is subject to different modes of gene regulations in systemic lupus erythematosus and rheumatoid arthritis patients.

[Morphology of immune inflammation in rheumatic diseases].

The results of combined histochemical, immunomorphological, and immunological studies on biopsy, operation, and autopsy materials from 184 patients with rheumatoid arthritis, 41 patients with systemic lupus erythematosus, 66 patients with systemic sclerodermia. 35 patients with periarteritis nodosa are summarized. The main morphological changes in rheumatic diseases were found to be due to immunopathological reactions manifested as immune inflammation.