The ECG of a 6-year-old girl.

A 12-channel ECG and the ECG patterb from Holter monitoring of a 6-year-girl are presented.

Diagnostic yield and variant reassessment in the genes encoding Nav1.5 channel in Russian patients with Brugada syndrome.

Brugada syndrome (BrS) is an inherited cardiac arrhythmia characterized by ST-elevation, negative T-wave, and a high risk of sudden cardiac death (SCD) due to ventricular tachycardia. It is associated with mutations in over 20 genes but only is recommended for routine genetic screening. This study was performed to estimate diagnostic yield and pathogenicity assessment of rare genetic variants in the genes encoding Nav1.

Variable Clinical Appearance of the Kir2.1 Rare Variants in Russian Patients with Long QT Syndrome.

Background: The gene encodes inward rectifier Kir2.1 channels, maintaining resting potential and cell excitability. Presumably, clinical phenotypes of mutation carriers correlate with ion permeability defects.

Coexistence of Two Rare Genetic Variants in Canonical and Non-canonical Exons of : A Potential Source of Misinterpretation.

Primary cardiac channelopathies are a group of diseases wherein the role of DNA testing in aiding diagnosis and treatment-based decision-making is gaining increasing attention. However, in some cases, evaluating the pathogenicity of new variants is still challenging. We report an accurate multistage assessment of a rare genetic variant in the gene using next-generation sequencing (NGS) techniques and Sanger sequencing.

[Cardiovascular Risks Associated with the use of Performance-Enhancing Stimulants].

The number of people involved in regular exercise and sports is increasing. Not infrequently, this is associated with intake of sports biologically active food supplements (BAS) and stimulators of physical ability. Data has been reported on the frequency of use of physical ability stimulators among professional athletes and on the use of the most popular food supplements among young people.

[QT Interval in Patients With COVID-19].

Since the first case recorded in the end of 2019, the virus SARS-CоV-2 and the related lung disease COVID-19 have spread over the world and became a threat for public health. The drugs used for treatment of this disease (azithromycin and hydroxychloroquine) can prolong the QT interval on the electrocardiogram to increase the risk of pirouette tachycardia and sudden cardiac death. This article presents a review of potential risks related with the drug treatment of COVID-19 and provides recommendations for management of patients during the pandemic.

[Syncope in Young Elite Athletes].

Unlabelled: Syncope - one of the most common syndrome in the general population - may be a manifestation of diseases associated with risk of sudden death.

Objective: To evaluate the prevalence, pathogenesis particular syncope, near syncope in children involved in elite sport.

Material And Methods: The study involved 500 young elite athletes aged 9-18 years (mean age 16.

[To the centennial of Norman Holter (1914-1983)].

The article is devoted to the centennial of the founder of ambulatory ECG monitoring Norman Jeffrey Holter (1914-1983). It contains brief history of the scientist's family, and depiction of his own educational way from magister of chemistry and physics to specialist in nuclear research. His activity during World War II, research related to impact of nuclear tests on environment after the war is also described.

[Microvolt T-wave alternans in adolescent elite athletes].

Unlabelled: Microvolt T-wave alternans (MTA) is one of markers of electrical myocardial instability.

Study Aim: To elucidate normal range of MTA parameters during bicycle exercise test (ET) in adolescent elite athletes.

Material And Methods: We examined 500 athletes aged 9-18 (mean 16.

[To the Centennial of Norman Holter (19141983)].

The article is devoted to the centennial of the founder of ambulatory ECG monitoring Norman Jeffrey Holter (1914-1983). It contains brief history of the scientists family, and depiction of his own educational way from magister of chemistry and physics to specialist in nuclear research. His activity during World War II, research related to impact of nuclear tests on environment after the war is also described.

[Microvolt T-Wave Alternans in Adolescent Elite Athletes].

Unlabelled: Microvolt T-wave alternans (MTA) is one of markers of electrical myocardial instability.

Study Aim: to elucidate normal range of MTA parameters during bicycle exercise test (ET) in adolescent elite athletes.

Material And Methods: We examined 500 athletes aged 9-18 (mean 16.

Characterization of 2 genetic variants of Na(v) 1.5-arginine 689 found in patients with cardiac arrhythmias.

Hundreds of genetic variants in SCN5A, the gene coding for the pore-forming subunit of the cardiac sodium channel, Na(v) 1.5, have been described in patients with cardiac channelopathies as well as in individuals from control cohorts. The aim of this study was to characterize the biophysical properties of 2 naturally occurring Na(v) 1.

[Andersen-Tawil syndrome. Efficacy of class IC drugs].

A case of a rare disease - Andersen-Tawil the syndrome (ATS) is presented. Diagnosis of ATS, 7-th molecular-genetic variant of long QT syndrome was made basing on the characteristic clinical picture (periodic stress induced syncopal states), data of ECG and its Holter monitoring (pronounced QT prolongation, bouts of polymorphic bidirectional ventricular tachycardia), typical dysmorphic features (low-set ears, small mandible, brachydactyly, fifth-digit clinodactyly). However mutation of the KCNJ2 gene typical for this variant was not detected.

[Changes of QT interval during graded exercise test in healthy adolescents aged 11-15 years].

Aim of the study was determination of physiological limits of QT-intervals and its derivative values in healthy children and adolescents during graded exercise tests. We examined 100 healthy boys and girls aged 11-15 years (mean age 13.4+/-2.

[Sudden death of two sisters in a family with combined progressive impairment of cardiac conduction system].

Sudden cardiac death (SCD) of two sisters from a family with combined progressive impairment of cardiac conduction system (CCS) is described. These two sisters (hetero-ovular twins) died suddenly in a kindergarten at the background of physical and emotional effort in the age of 4.8 and 5 years.

Microvolt T-wave alternans during Holter monitoring in children and adolescents.

Background: Time-domain microvolt T-wave alternans (TWA) has been described as a noninvasive marker of sudden cardiac death in adults. The incidence of TWA in pediatric populations has not been defined well. The aim of the study was to determine peculiarities of TWA in children.

QT dynamicity, microvolt T-wave alternans, and heart rate variability during 24-hour ambulatory electrocardiogram monitoring in the healthy newborn of first to fourth day of life.

Background: Twenty-four hour ambulatory electrocardiogram (AECG) monitoring is an established technique for integrated assessment of heart rhythm; however, comprehensive description of serial changes in cardiac electrophysiology over the first days of life in humans is lacking. The aim of this study was to determine the patterns of circadian heart rhythm based on AECG evaluation in newborns.

Methods: Twenty healthy newborns (14 boys and 6 girls) were serially examined with AECG at days 1, 2, and 4 after birth.

[Sudden out of hospital cardiac death in children, adolescents, and subjects younger than 45 years].

Aim of this study was determination of incidence and structure of sudden out of hospital cardiac death (SCD) in subjects aged 1-45 years in Moscow. We analyzed rate and structure of SD among persons who had succumbed in 2005-2007 in several districts of Moscow with population of 2,502,836. Of the total number of 19,557 autopsies 7702 (39.

Correlation of inhibition of platelet aggregation after clopidogrel with post discharge bleeding events: assessment by different bleeding classifications.

Aims: To correlate inhibition of platelet aggregation (IPA) with bleeding events assessed by TIMI, GUSTO, and BleedScore scales in a large cohort of patients with coronary artery disease (CAD) and ischaemic stroke (IS) treated with chronic low-dose aspirin plus clopidogrel. Data from recent trials and registries suggest a link between increased risk of bleeding and cardiovascular mortality. However, the potential association of bleeding risk and IPA is not established.

[Holter monitoring in healthy children during first days of life].

Aim of the study was to determine dynamics of main parameters of heart rhythm in children during first days of life. Material and methods. We examined 30 healthy newborns (14 boys and 16 girls) aged 1-4 days (2,6+/-1,3 days).