The Exposome and Cardiovascular Health: Webcast December 12 2024.

This 61-minute webcast features a conversation about "The Exposome and Cardiovascular Health"-the focus of Issue 20.5. Led by the issue's editors, the discussion engages the authors on emerging themes and lessons learned while researching and writing the articles.

Lung function may recover after coal mine fire smoke exposure: a longitudinal cohort study.

Background And Objective: The 2014 Hazelwood coal mine fire exposed residents in nearby Morwell to high concentrations of particulate matter <2.5 µm (PM) for approximately 6 weeks. This analysis aimed to evaluate the long-term impact on respiratory health.

A Review of the Links Between Work and Heart Disease in the 21st Century.

This review explores the multifaceted exposures in the workplace that contribute to cardiovascular diseases (CVD), including physical, ergonomics, chemical, biological, psychosocial, and emerging occupational hazards. These well-documented occupational hazards have long been linked to heart disease. Exposures arising from these hazards present significant concerns for worker health and safety.

Exclusion of non-Involved uterus from the target volume (EXIT-trial): An individualized treatment for locally advanced cervical cancer using modern radiotherapy and imaging techniques followed by completion surgery.

Background And Purpose: Chemoradiotherapy followed by brachytherapy is the standard of care for locally advanced cervical cancer (LACC). In this study, we postulate that omitting an iconographical unaffected uterus (+12 mm distance from the tumour) from the treatment volume is safe and that no tumour will be found in the non-targeted uterus (NTU) leading to reduction of high-dose volumes of surrounding organs at risk (OARs).

Material And Methods: In this single-arm phase 2 study, two sets of target volumes were delineated: one standard-volume (whole uterus) and an EXIT-volume (exclusion of non-tumour-bearing parts of the uterus with a minimum 12 mm margin from the tumour).

Timing of radiotherapy (RT) after radical prostatectomy (RP): long-term outcomes in the RADICALS-RT trial (NCT00541047).

Background: The optimal timing of radiotherapy (RT) after radical prostatectomy for prostate cancer has been uncertain. RADICALS-RT compared efficacy and safety of adjuvant RT versus an observation policy with salvage RT for prostate-specific antigen (PSA) failure.

Patients And Methods: RADICALS-RT was a randomised controlled trial enrolling patients with ≥1 risk factor (pT3/4, Gleason 7-10, positive margins, preoperative PSA≥10 ng/ml) for recurrence after radical prostatectomy.

Coastal Bathymetric Sounding in Very Shallow Water Using USV: Study of Public Beach in Gdynia, Poland.

The bathymetric surveys executed with a use of small survey vessels in limited water areas, including offshore areas, require precise determination of the geospatial coordinates of the seabed which is a synthesis of, among others, determining the position coordinates and measuring the depth. Inclination of the seabed and the declining depth make manoeuvring of the sounding vessel, e.g.

Completion surgery after intensity-modulated arc therapy for locally advanced cervical cancer: long-term follow-up and update on surgical outcome and oncologic results of a unique tertiary care single-center retrospective cohort.

Background: Chemoradiotherapy (CRT) followed by brachytherapy (BT) is the standard treatment for locally advanced cervical cancer (LACC), but replacement of BT by surgery (CRT-S) could be an acceptable alternative. The main concern is the risk of operative morbidity. The aim is to report on therapeutic morbidity, OS, PC, and LC of CRT-S.

Determination of USV's Direction Using Satellite and Fluxgate Compasses and GNSS-RTK.

The measurement of a mobile object's movement direction is performed by means of various analogue and digital devices, including both autonomous and non-autonomous ones. They represent different measuring qualities, dimensions, weights and tolerance to ambient disturbances. They allow measuring the course of heading and course over ground (COG) in sea navigation.

Cervical cancer screening and outcomes for women under 25 years of age in Belgium: a 10-year nationwide study.

Objective: The aim of the study was to describe trends in cervical cancer screening and outcomes for women under 25 years of age in Belgium between 2010 and 2019 in response to a changed reimbursement policy.

Materials And Methods: We used the databases of the National Health Insurance Institute (RIZIV/INAMI) and the Belgian Cancer Registry (BCR) for a nationwide description of cervical screening, subsequent diagnostic procedures and outcomes for women younger than 20 years and women aged 20-25 years between 2010 and 2019.

Results: Over a 10-year period, the number of cytology screening tests and annual screening rates in women younger than 25 years have been reduced by 50%, but no increases in invasive cervical cancer or high-grade intraepithelial lesion diagnoses were observed.

Croatian genetic heritage: an updated Y-chromosome story.

Aim: To analyze an additional set of ˝Y-chromosome genetic markers to acquire a more detailed insight into the diversity of the Croatian population.

Methods: A total of 518 Yfiler Plus profiles were genotyped. Allele frequencies, haplotype frequencies, and haplotype diversity were calculated by using the STRAF software v.

Synthesis, physico-chemical properties and effect of adenosine thiamine triphosphate on vitamin B metabolism in the liver of alloxan diabetic rats.

Background: Adenosine thiamine triphosphate (AThTP) is a nucleotide discovered in bacteria and some other living organisms more than a decade ago. No biochemical function for AThTP has been established yet, however, experimental data available indicate its possible involvement in metabolic regulation or cell signaling. Metabolism of AThTP in mammals, as well as the feasibility of its pharmacological application, is essentially unstudied.

Survey: acceptability of opportunistic bilateral salpingectomy in Flanders.

Background: The VVOG (Flemish Society of Obstetrics and Gynaecology) published a consensus statement promoting opportunistic bilateral salpingectomy (OBS).

Objectives: The aim of the study was to obtain insight into the current opinion and general practice of Flemish gynaecologists to counsel and perform OBS.

Materials And Methods: A questionnaire was distributed to Flemish gynaecologists three months following publication.

Are e-cigarette use and vaping associated with increased respiratory symptoms and poorer lung function in a population exposed to smoke from a coal mine fire?

Background And Objective: E-cigarette use has become increasingly prevalent, but there is some evidence demonstrating potential harms with frequent use. We aimed to identify the profiles of e-cigarette users from a regional community in Australia and investigate the associations of e-cigarettes with respiratory symptoms and lung function.

Methods: A total of 519 participants completed a cross-sectional study.

Long-term impact of coal mine fire smoke on lung mechanics in exposed adults.

Background And Objective: In 2014, a 6-week-long fire at the Hazelwood coal mine exposed residents in the adjacent town of Morwell to high concentrations of fine particulate matter with an aerodynamic diameter < 2.5 μm (PM ). The long-term health consequences are being evaluated as part of the Hazelwood Health Study.

The impact of the Hazelwood coal mine fire smoke exposure on asthma.

Objective: In 2014, a fire at an open cut coal mine in South-eastern Australia burned for about 6 weeks. Residents of the adjacent town were exposed to high levels of fine particulate matter (PM) during this period. Three and a half years after the event, this study aimed to investigate potential long-term impacts of short-term exposure to coal mine fire smoke on asthma.

Effect of occipitoatlantal decompression on cerebral blood flow dynamics as evaluated by Doppler ultrasonography.

Context: Osteopathic manipulative treatment reduces symptoms in patients with headache disorders, but the underlying mechanisms are unclear.

Objective: To evaluate blood flow in the intracranial and extracranial vasculature before and after occipitoatlantal decompression (OAD) using Doppler ultrasonography.

Methods: Healthy, first-year osteopathic medical students from A.

Autophagy Brings an END to Aberrant Endocytosis.

Wilfling et al. (2020) characterize a selective autophagy pathway in yeast for early clathrin-mediated endocytosis (CME) proteins facilitated by the phase separation of the CME protein, Ede1, which acts as an intrinsic autophagy receptor for the degradation of Ede1-dependent endocytic protein deposits (ENDs).

Seabed Topography Changes in the Sopot Pier Zone in 2010-2018 Influenced by Tombolo Phenomenon.

Bathymetric surveys of the same body of water, performed at regular intervals, apart from updating the geospatial information used to create paper and electronic maps, allow for several additional analyses, including an evaluation of geomorphological changes occurring in the coastal zone. This research is particularly important in places where the shape of the coastal zone has been violently disturbed, including by human activity. Tombolo is such a phenomenon and it dynamically shapes the new hydrological conditions of the coastal zone.

Splenic F-FDG uptake on baseline PET/CT is associated with oncological outcomes and tumor immune state in uterine cervical cancer.

Objective: The spleen represents an important contributor to tumor immune escape, but the relevance of increased splenic metabolic activity remains to be fully elucidated.

Methods: We retrospectively measured the spleen-to-liver standard uptake value (SLR) on F-FDG PET/CT examinations of 92 consecutive patients with FIGO stage IB1 to IVA cervical cancer and integrated the results with survival, response to treatment, tumor immune infiltrate, and baseline characteristics.

Results: SLR > 0.

Using UAV Photogrammetry to Analyse Changes in the Coastal Zone Based on the Sopot Tombolo (Salient) Measurement Project.

The main factors influencing the shape of the beach, shoreline and seabed include undulation, wind and coastal currents. These phenomena cause continuous and multidimensional changes in the shape of the seabed and the Earth's surface, and when they occur in an area of intense human activity, they should be constantly monitored. In 2018 and 2019, several measurement campaigns took place in the littoral zone in Sopot, related to the intensive uplift of the seabed and beach caused by the tombolo phenomenon.