Publications by authors named "Maka M Alexishvili"
Article Synopsis
- The study examines how chlorpromazine and promethazine interact in rabbits when administered together versus separately.
- When given at the same time, the presence of each drug affects the other's absorption and how long they stay in the bloodstream, potentially due to liver processing and micelle formation in the digestive system.
- Chlorpromazine is rapidly taken up by the liver, influencing the levels and duration of promethazine in circulation, while promethazine alters chlorpromazine's metabolism, indicating a complex interplay between the two drugs.
The interaction of carbamazepine and promethazine in rabbits has been investigated. The influence of this interaction on the processes of biotransformation in the liver was revealed. The drugs were administered as single oral doses (100 mg of each drug) as well as simultaneously with an interval of 15 min.
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